The bioactivity-guided isolation on the Scutellaria barbata extract resulted in the purification of four undescribed neo-clerodane diterpenoids, scuttenlines A–D (1–4), alone with 20 known diterpenoids (5–24). The chemical structures of them were elaborated by extensive spectroscopic means, including 1D, 2D-NMR and HR-MS. The anti-inflammatory potential ability of 1–24 was screened in lipopolysaccharide-stimulated mouse RAW 264.7 cells. Scuttenline C (IC₅₀=1.9 μM) and 18 (IC₅₀=3.7 μM) exhibited potent activity to inhibit NO production.

中文翻译：

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具有抗炎活性的半枝莲地上部分的新克罗丹二萜

黄芩提取物的生物活性引导分离导致纯化了四种未描述的新灯丹二萜，scuttenlines A-D ( 1-4 ) ，仅与 20 种已知的二萜( 5-24 ) 。它们的化学结构通过广泛的光谱手段进行了详细阐述，包括 1D、2D-NMR 和 HR-MS。在脂多糖刺激的小鼠 RAW 264.7 细胞中筛选出1-24的抗炎潜力。Scuttenline C (IC ₅₀ =1.9 μM) 和18 (IC ₅₀=3.7 μM) 表现出抑制 NO 产生的有效活性。