Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil

de Veras, Bruno Oliveira; Santos, Yago Queiroz dos; da Silva Oliveira, Fernanda Granja; da Silva Almeida, Jackson Roberto Guedes; da Silva, Alexandre Gomes; Correia, Maria Tereza dos Santos; Diniz, Katharina Marques; de Oliveira, João Ricardhis Saturnino; de Menezes Lima, Vera Lúcia; Navarro, Daniela Maria do Amaral Ferraz; de Oliveira Farias de Aguiar, Júlio César Ribeiro; de Oliveira, Maria Betânia Melo; de Souza Lopes, Ana Catarina; da Silva, Márcia Vanusa

doi:10.6084/m9.figshare.8033834.v2

gnpl_a_1602832_sm8820.pdf (834.8 kB)

Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil

Version 2 2020-10-07, 11:10

Version 1 2019-04-24, 06:01

journal contribution

posted on 2020-10-07, 11:10 authored by Bruno Oliveira de Veras, Yago Queiroz dos Santos, Fernanda Granja da Silva Oliveira, Jackson Roberto Guedes da Silva Almeida, Alexandre Gomes da Silva, Maria Tereza dos Santos Correia, Katharina Marques Diniz, João Ricardhis Saturnino de Oliveira, Vera Lúcia de Menezes Lima, Daniela Maria do Amaral Ferraz Navarro, Júlio César Ribeiro de Oliveira Farias de Aguiar, Maria Betânia Melo de Oliveira, Ana Catarina de Souza Lopes, Márcia Vanusa da Silva

This work aimed to investigate the chemical composition, antimicrobial, antinociceptive, acute toxicity and antioxidant activity of the essential oil of Algrizea minor (EOAm). The essential oil presented as the major constituents β-Pinene (56.99%), α-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene (4.66%), (E)-Caryophyllene (3.76%) and Limonene (1.71%). It was verified that the essential oil did not show acute toxicity in the maximum dose of 5,000 mg/kg. In the evaluation of the antinociceptive activity it was verified that the essential oil reduced in 65.84% the number of writhing in the mice, reducing the pain in 59.17%, and the mechanism of action in pain reduction was opioid, similar to morphine. The essential oil also presented significant antimicrobial against Gram positive and Gram-negative bacteria and fungi, and the antioxidant activity was relevant. Therefore, these results demonstrate the great potential for the future development of pharmaceutical products with the essential oil of Algrizea minor (EOAm).