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The Phytochemistry and Pharmacology of Hypericum

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Progress in the Chemistry of Organic Natural Products 112

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 112))

Abstract

Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The constituents of Hypericum species are valued for their important biological properties. Their use is in the treatment of depression and as antibacterial agents has been well documented in the primary literature and in ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents of members of the genus Hypericum and their biological effects. A detailed account of the chemical constituents, including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids, is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects.

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Acknowledgments

The authors are most grateful for the careful and meticulous editing of Professor Heinz Falk (Johannes Kepler University, Linz), during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Natural Medicine, School of Pharmacy, Shanghai Engineering Research Center of Immuno Therapeutics, Fudan University, 826 Zhangheng Road, Zhangjiang Pudong, Shanghai, 201203, China

    Chuan-Yun Xiao & Qing Mu

  2. School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK

    Simon Gibbons

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  1. Chuan-Yun Xiao
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  2. Qing Mu
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  3. Simon Gibbons
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Correspondence to Chuan-Yun Xiao .

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Editors and Affiliations

  1. College of Pharmacy, The Ohio State University, Columbus, OH, USA

    A. Douglas Kinghorn

  2. Institute of Organic Chemistry, Johannes Kepler University, Linz, Oberösterreich, Austria

    Heinz Falk

  3. School of Pharmacy, University of East Anglia, Norwich, UK

    Simon Gibbons

  4. Graduate School of Pharmaceutical Science, Hokkaido University, Fukuoka, Japan

    Jun'ichi Kobayashi

  5. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  6. School of Pharmaceutical Sciences, South Central University for Nationalities, Wuhan, China

    Ji-Kai Liu

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Xiao, CY., Mu, Q., Gibbons, S. (2020). The Phytochemistry and Pharmacology of Hypericum. In: Kinghorn, A.D., Falk, H., Gibbons, S., Kobayashi, J., Asakawa, Y., Liu, JK. (eds) Progress in the Chemistry of Organic Natural Products 112. Progress in the Chemistry of Organic Natural Products, vol 112. Springer, Cham. https://doi.org/10.1007/978-3-030-52966-6_2

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