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Effect of aqueous extract of Allium saralicum R.M. Fritsch on fatty liver induced by high-fat diet in Wistar rats

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Abstract

The fatty liver as a metabolic disorder has involved human beings globally and is usually followed by extreme obesity, increased blood lipid, and diabetes type II. Appropriate strategies for treating this disease are prioritized by each country. The aim of the recent research was to survey the remedial potential of aqueous extract of Allium saralicum R.M. Fritsch on the high-fat diet-induced fatty liver disease in Wistar male rats. In this study, 60 rats were used. A total of 10 rats were selected as the negative control, and the rest of them were treated with a high-fat diet for 4 months. Then, the animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the aqueous extract of A. saralicum at 20, 40, 80, and 160 mg/kg concentrations. After 2 months, the rats were sacrificed and blood and liver samples of them were collected to analyze the biochemical and histopathological parameters. The data were analyzed by SPSS-21 software. All doses of A. saralicum (especially A160) could significantly (p ≤ 0.05) decrease the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, glucose, and GR and increased HDL, total protein, albumin, SOD, CAT, and GPx as compared to the untreated group. Also, aqueous extract of A. saralicum (especially A160) decreased the degree of hepatic steatosis as compared to the untreated group. In conclusion, the acquired results showed the hepatoprotective potential of aqueous extract of A. saralicum, so that it can use for the treatment of fatty liver disease.

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Authors and Affiliations

  1. Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran

    Rohallah Moradi, Majid Hajialiani, Akram Zangeneh & Mohammad Mahdi Zangeneh

  2. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran

    Majid Hajialiani

  3. Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran

    Saman Salmani, Maryam Almasi, Akram Zangeneh & Mohammad Mahdi Zangeneh

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  1. Rohallah Moradi
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  2. Majid Hajialiani
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  3. Saman Salmani
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  4. Maryam Almasi
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  5. Akram Zangeneh
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  6. Mohammad Mahdi Zangeneh
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Correspondence to Akram Zangeneh.

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All institutional and national guidelines for the care and use of laboratory animals were followed.

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Moradi, R., Hajialiani, M., Salmani, S. et al. Effect of aqueous extract of Allium saralicum R.M. Fritsch on fatty liver induced by high-fat diet in Wistar rats. Comp Clin Pathol 28, 1205–1211 (2019). https://doi.org/10.1007/s00580-018-2834-y

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  • DOI: https://doi.org/10.1007/s00580-018-2834-y

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