Two new species of Loeselia (Polemoniaceae) from central Mexico are described and illustrated. Both are known only from small areas in the Balsas Depression of the state of Michoacán. Loeselia tancitaroensis occurs in pine-oak forest on the foothills of Cerro Tancítaro. It is similar to the Oaxacan endemic L. ruprestis, from which it differs in possessing linear to linear-lanceolate inflorescence bracts, entire to rarely one-toothed floral bracts and sepals, shorter sepals and ovaries, and carpels with two ovules. Loeselia spectabilis is restricted to tropical deciduous forest in the Infiernillo region. It is distinguished from the closely related L. grandiflora by possessing petiolate leaves, shorter sepals, glandular-ciliate corolla margins, and carpels with a single ovule.