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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Nature
Here we report prime editor engineered virus-like particles (PE-eVLPs) that deliver prime editor proteins, prime editing guide RNAs and nicking single guide...
9 months ago

Light-Induced Transformation of Virus-Like Particles on TiO2

ACS Publications
This study provides insights into the impact of UV-A light on the photocatalytic inactivation of adsorbed SARS-CoV-2 virus-like particles (VLPs) on a TiO 2...
3 months ago

Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

Journal of Translational Medicine
We generated a highly immunogenic vaccine platform based on engineered HIV-1 Gag-based Virus-Like Particles (VLPs) expressing a high copy number of each in...
9 months ago

Computational method for designing vaccines applied to virus-like particles (VLPs) as epitope carriers

ScienceDirect.com
Nonenveloped virus-like particles (VLPs) are self-assembled oligomeric structures composed of one or more proteins that originate from diverse viruses.
3 months ago

Increased efficacy of influenza virus vaccine candidate through display of recombinant neuraminidase on virus like particles

Frontiers
Vaccination against influenza virus can reduce the risk of influenza by 40% to 60%, they rely on the production of neutralizing antibodies specific to...
4 months ago

‘It’s insane’: New viruslike entities found in human gut microbes

Science | AAAS
The latest, reported this week in a preprint, is a new kind of viruslike entity that inhabits bacteria dwelling in the human mouth and gut.
8 months ago

Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers

Nature
Virus-like particles with preferential uptake by DCs may facilitate the development of potent prophylactic and therapeutic vaccines.
5 months ago

Surface Cross-Linking by Macromolecular Tethers Enhances Virus-like Particles’ Resilience to Mucosal Stress Factors

ACS Publications
Virus-like particles (VLPs) are emerging as nanoscaffolds in a variety of biomedical applications including delivery of vaccine antigens and cargo such as...
8 months ago

CHO cells for virus-like particle and subunit vaccine manufacturing

ScienceDirect.com
Chinese Hamster Ovary (CHO) cells, employed primarily for manufacturing monoclonal antibodies and other recombinant protein (r-protein) therapeutics,
6 months ago

Analyzing atomic force microscopy images of virus-like particles by expectation-maximization

Nature
Analysis of virus-like particles (VLPs) is an essential task in optimizing their implementation as vaccine antigens for virus-initiated diseases.
3 months ago