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Poly ADP-ribose signaling is dysregulated in Huntington disease

PNAS
Accumulation of poly adenosine diphosphate (ADP)-ribose (PAR) has been implicated in Alzheimer and Parkinson diseases, as well as cerebellar ataxia. We report...
2 weeks ago

Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy

Nature
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Its complexity is influenced by various signal transduction...
6 days ago

A cholinergic signaling pathway underlying cortical circuit activation of quiescent neural stem cells in the lateral ventricle

Science | AAAS
3A, 4A, 5A, and 6A). These findings elucidate the molecular mechanisms governing the regulation of ventral quiescent LV NSCs by cortical circuits. In humans,...
3 weeks ago

Federal Reserve signals end to inflation fight with a sizable half-point rate cut

AP News
The Federal Reserve cut its benchmark interest rate by an unusually large half-point, a dramatic shift after more than two years of high rates helped tame...
3 weeks ago

In Praise of Climate Virtue Signaling

WIRED
Decisions around climate change and our individual behavior do have a moral component. It's not to say that if someone takes an extra flight each year it makes...
3 weeks ago

Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice

Nature
Social memory impairment is a key symptom of many brain disorders, but its underlying mechanisms remain unclear. Neuroligins (NLGs) are a family of cell...
1 week ago

The brassinosteroid receptor gene BRI1 safeguards cell-autonomous brassinosteroid signaling across tissues

Science | AAAS
Brassinosteroid signaling is essential for plant growth as exemplified by the dwarf phenotype of loss-of-function mutants in BRASSINOSTEROID INSENSITIVE 1...
2 weeks ago

Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury

PNAS
Our research reveals that lipin1 functions as a central regulator to coordinate mTOR and STAT3 signaling pathways in the CNS neurons.
3 weeks ago

Israel extends evacuation warnings in Lebanon, signaling a wider offensive

AP News
The Israeli military has warned people to evacuate a city and other communities in southern Lebanon that are north of a U.N.-declared buffer zone.
1 week ago

The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity

Nature
The cell-envelope of Gram-negative bacteria contains endotoxic lipopolysaccharides (LPS) that are recognized by the innate immune system via Toll-Like...
2 weeks ago