The Cancer Signaling and Microenvironment (CSM) Program studies signaling processes, their cancer cell-intrinsic adaptation, and how they are affected by...
16 months ago

The CCSR's goal is to create a self-sustaining research community at UNE in the cell signaling field, which represents an important component of UNE's mission...
7 months ago

Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of...
189 months ago

In this review we discuss the two faces of ROS — redox biology and oxidative stress — and their contribution to both physiological and...
124 months ago

In mice, dopamine release in the brain increased the abundance and activity of the enzyme neprilysin, which degraded amyloid-β specifically in the working...
2 months ago

This intricate crosstalk is crucial to shaping the diverse biological functions of NF-κB into cell type– and context-specific responses.
158 months ago

IMPALA identified pathways were associated with Tamoxifen resistance and an increased risk of breast cancer recurrence.
44 months ago

Here we review recent advances in Jak–STAT biology, focusing on immune cell function, disease etiology and therapeutic intervention.
90 months ago

In this paper, we reviewed these two aspects in the field of failing heart signaling cascades and emerging therapeutic strategies based on modern biological...
29 months ago

The identified mechanisms of PD include α-synuclein aggregation, oxidative stress, ferroptosis, mitochondrial dysfunction, neuroinflammation,...
19 months ago