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Calcium Signaling in Health and Disease Group

National Institute of Environmental Health Sciences (.gov)
The Calcium Signaling in Health & Disease Group studies how aberrant calcium signals may contribute to disease in humans, particularly allergies and asthma.
2 weeks ago

Signaling Alaska: By land, by sea and by air

Juneau Empire
As Juneau's public broadcasting station KTOO celebrates its 50th anniversary its legacy is built on a public communications system started...
2 days ago

Inducing a gene that informs cell signaling could halt diabetic kidney disease, study shows

Medical Xpress
New research by Stony Brook Medicine nephrology specialists that centers on targeting key cellular signaling between two types of kidney...
2 days ago

A Flash In the Pan

UConn Today
Measuring a thought has always been difficult. Neuroscientists have some clever ways, but now University of Connecticut researchers describe...
5 days ago

Inositol Signaling Group

National Institute of Environmental Health Sciences (.gov)
Shears, Ph.D., is head of the Inositol Signaling Group and holds a secondary appointment in the NIEHS Immunity, Inflammation, and Disease Laboratory. The...
2 weeks ago

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

Science | AAAS
In mice, dopamine release in the brain increased the abundance and activity of the enzyme neprilysin, which degraded amyloid-β specifically in the working...
2 months ago

Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling

Nature
Autophagy-mediated chemoresistance is the core mechanism for therapeutic failure and poor prognosis in breast cancer.
1 day ago

Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB

Nature
Although there have been advances in understanding colorectal cancer (CRC) pathogenesis, significant gaps still exist, highlighting the need...
1 day ago

Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue

Nature
Here, we show the role of endothelin 3 (EDN3) and endothelin receptor type B (EDNRB) in promoting the browning of white adipose tissue (WAT).
1 month ago

Intrinsic signaling pathways modulate targeted protein degradation

Nature
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully...
3 months ago