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Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model

Science | AAAS
Infection with herpes simplex virus type 1 (HSV-1) in the brains of APOE4 carriers increases the risk of Alzheimer's disease (AD). We previously found that...
2 weeks ago

KRAS Oncoprotein Signaling in Cancer

The New England Journal of Medicine
Recent studies provide new insights into signaling by mutant KRAS, inhibitors of which have provided modest benefits for patients.
1 week ago

PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways

Nature
Post-translational modifications (PTMs) play pivotal roles in regulating cellular signaling, fine-tuning protein function, and orchestrating complex...
2 weeks ago

Why is Mark Zuckerberg vice-signaling?

Max Read | Substack
Greetings from Read Max HQ, free of norovirus for nearly one week! This week I had the pleasure of appearing on Van Jackson's stream/podcast Undiplomatic,...
2 weeks ago

Adipocyte-derived ferroptotic signaling mitigates obesity

ScienceDirect.com
Ferroptosis is characterized as an iron-dependent and lipophilic form of cell death. However, it remains unclear what role ferroptosis has in adipose tissue...
4 weeks ago

Engineering synthetic phosphorylation signaling networks in human cells

Science | AAAS
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation...
3 weeks ago

Starbucks Union Files 34 Federal Complaints, Signaling Renewed Hostilities

Yahoo Finance
(Bloomberg) -- Starbucks Corp.'s union filed 34 US labor board complaints against the company this week, signaling rising tension between the coffee chain...
2 weeks ago

Signaling circuit interplay pushes newborn neurons out of the neuronal nest

St. Jude Children's Research Hospital
See how Netrin-1, Siah2, Pard3 and JamC interconnect in a coincidence detection circuit in neuronal development and migration from germinal zone.
2 weeks ago

Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway

Nature
Regulator of G protein signaling 1 (RGS1) is known to be highly expressed in various tumors, but its specific effects and regulatory mechanism in ovarian...
2 weeks ago

Role of Nrf2/HO-1 and cytoglobin signaling in the protective effect of indole-3-acetic acid and chenodeoxycholic acid against kidney injury induced by valproate

ScienceDirect.com
IAA and CDCA alleviated the kidney injury induced by VPA via downregulating the inflammatory response and upregulating the antioxidant capacity in renal tissue.
3 weeks ago