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Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling

Nature
The discovery of Toll-like receptors (TLRs) represented a significant breakthrough that paved the way for the study of host-pathogen interactions in innate...
4 weeks ago

Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells

Science | AAAS
SLIT-ROBO signaling regulates pathological ocular neovascularization, which is a major cause of vision loss worldwide, but pharmacological tools to prevent SLIT...
3 weeks ago

Modulatory Role of Pantropic Cell Signaling Pathways in the Antimigratory and Antiproliferative Action of Triazole Chelated Iridium(III) Complexes in Cervical Cancer Cells

ACS Publications
The iridium(III) complexes restrict cervical cancer cell migration and proliferation by exerting pronounced effects as P53 activators and downregulation of ERK...
1 month ago

Light-sensitive Ca2+ signaling in the mammalian choroid

PNAS
As a key second messenger and regulator of vasculature function, Ca2+ dynamics in endothelial cells and mural cells of the choroid could be key targets of light...
3 weeks ago

Activating a protein signaling pathway slows prostate cancer growth

News-Medical
A special protein can play a key role in the fight against certain types of prostate cancer. This is shown in a study by an international research group led...
3 days ago

WPI Adopts Okanagan Charter, Signaling Ongoing Commitment to Holistic Wellbeing of People, Places, and the Planet

Worcester Polytechnic Institute
“WPI is proud to adopt the Okanagan Charter and recognizes that an individual's well-being is critically connected with their communities and environments,”...
4 weeks ago

JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination

Nature
Unipotent basal and luminal stem cells maintain prostate homeostasis, with an intermediate cell population emerging during prostate inflammation or cancer.
4 weeks ago

Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy

Science | AAAS
Type I interferons (IFNs) stimulate antiviral or antiproliferative signaling in a cell type–dependent manner. The Janus kinases TYK2 and JAK1 are recruited...
3 weeks ago

Researchers discover new receptor in pain signaling pathway

News-Medical
Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it...
2 days ago

Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids

Nature
Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular...
3 weeks ago