Science Signaling publishes studies that provide mechanistic insights into physiology and disease, identify new therapeutic targets, and characterize drugs.
39 months ago

The Cancer Signaling and Microenvironment (CSM) Program studies signaling processes, their cancer cell-intrinsic adaptation, and how they are affected by...
18 months ago

The CCSR's goal is to create a self-sustaining research community at UNE in the cell signaling field, which represents an important component of UNE's mission...
9 months ago

Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of...
191 months ago

In this review we discuss the two faces of ROS — redox biology and oxidative stress — and their contribution to both physiological and...
126 months ago

Endosomal Signaling Is Tightly Controlled. Endosomal Proteolysis Attenuates Signaling. Deubiquitinating Proteases (DUBs) Control Endosomal Trafficking and...
33 months ago

Salter et al. used phosphoproteomics to compare the activities of CARs encoding CD28 or 4-1BB costimulatory domains in primary human T cells.
75 months ago

Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs.
51 months ago

These results demonstrate that protein phase separation can create a distinct physical and biochemical compartment that facilitates signaling.
38 months ago

In this review, we discuss cellular signaling pathways involved in immunometabolic regulation, including relevant molecules, upstream and downstream targets.
56 months ago