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Science Signaling | AAAS
Science | AAAS
Science Signaling publishes studies that provide mechanistic insights into physiology and disease, identify new therapeutic targets, and characterize drugs.
2 days ago
Unveiling the critical role of androgen receptor signaling in avian sexual development
Nature
Gonadal hormone activities mediated by androgen and estrogen receptors, along with cell-autonomous mechanisms arising from the absence of sex-chromosome...
3 weeks ago
Nutrients and organelle signaling shape tissue immunity
St. Jude Children's Research Hospital
Nutrients and organelle signaling shape tissue immunity. Scientists at St. Jude Children's Research Hospital have shown that nutrient availability and organelle...
3 weeks ago
10th Pickart Lecture: Signaling through the ubiquitin-proteasome system
Johns Hopkins Bloomberg School of Public Health
Her lab discovers and defines ubiquitylation pathways and mechanisms. Structures from the Schulman lab have defined fundamental enzymology of the major classes...
3 weeks ago
North Korea launches long-range missile, signaling tech improvements
Defense News
The launch was likely meant to meant grab American attention days before the U.S. election and respond to condemnation over the North's role in Ukraine.
1 week ago
Cell - Signaling, Metabolism, Division
Britannica
Plasmodesmata. Similar to the gap junction of animal cells is the plasmodesma, a channel passing through the cell wall and allowing direct molecular...
1 week ago
eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations
PNAS
Inhibition of eIF4F disrupts this negative feedback control and leads to hyperactivation of ERK. This suggests that eIF4F plays a critical role in maintaining...
2 weeks ago
Activation of a helper NLR by plant and bacterial TIR immune signaling
Science | AAAS
Plant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain sense pathogen...
23 hours ago
Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells
Nature
While prostaglandin E2 (PGE2) is produced in human tumor microenvironment (TME), its role therein remains poorly understood. Here, we examine this issue by...
6 days ago
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity
Science | AAAS
Our data indicate that partial loss of ANP/GCA signaling specifically in skeletal muscle is sufficient to cause systemic insulin resistance and prediabetes...
1 month ago