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Re-engineered, blue light-activated immune cells penetrate and kill solid tumors
Penn State University
A team led by researchers from the Penn State College of Medicine re-engineered immune cells with a light-activated switch that modulates protein function...
3 weeks ago
Engineered T cell therapy for central nervous system injury
Nature
Traumatic injuries to the central nervous system (CNS) afflict millions of individuals worldwide1, yet an effective treatment remains elusive.
2 months ago
Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas–based epigenome editing in Alzheimer’s disease
Science | AAAS
These results suggest that MAPLEX is an efficient intracellular protein delivery system that can deliver diverse therapeutic proteins for multiple diseases.
3 months ago
Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis
Nature
Mounting evidence indicates that antibodies can contribute towards control of tuberculosis (TB). However, the underlying mechanisms of humoral immune...
2 months ago
Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles
Nature
Clinical implementation of therapeutic genome editing relies on efficient in vivo delivery and the safety of CRISPR-Cas tools.
6 days ago
Van der Waals polarity-engineered 3D integration of 2D complementary logic
Nature
Vertical three-dimensional integration of two-dimensional (2D) semiconductors holds great promise, as it offers the possibility to scale up logic layers in...
5 months ago
Engineered probiotic Escherichia coli elicits immediate and long-term protection against influenza A virus in mice
Nature
We show that intranasal administration of probiotic Escherichia coli Nissle 1917 activates innate immunity in the respiratory tract and provides immediate...
3 months ago
Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane
Nature
The application of organoids has been limited by the lack of methods for producing uniformly mature organoids at scale. This study introduces an organoid...
2 weeks ago
An engineered enzyme embedded into PLA to make self-biodegradable plastic
Nature
Since the first report of enzymatic hydrolysis of PLA by the proteinase K from Tritirachium album, numerous studies have demonstrated microbial and enzymatic...
3 months ago
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo
Nature
Here we report prime editor engineered virus-like particles (PE-eVLPs) that deliver prime editor proteins, prime editing guide RNAs and nicking single guide...
10 months ago