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Ophthalmic acid: An alternative neurotransmitter

Tech Explorist
A molecule in the brain – ophthalmic acid – unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function.
2 days ago

neurons in dorsal bed nucleus of the stria terminalis for mediating depression-related behaviors

Nature
Dopamine (DA) neurons play a crucial role in the development and manifestation of depression, as well as in response to antidepressant treatments.
4 days ago

A schizophrenia win for BMS’ Cobenfy, but challenges lie ahead

Clinical Trials Arena
For over 60 years, the dopaminergic hypothesis of schizophrenia has formed the basis of the schizophrenia treatment paradigm.
5 days ago

Parkinson's motor symptoms improve with tavapadon in Phase 3 clinical trial

Parkinson's News Today
The TEMPO-1 study tested the efficacy, safety, and tolerability of tavapadon to assess changes in the severity of Parkinson's motor symptoms.
1 week ago

Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation

Nature
Spatial memories guide navigation efficiently toward desired destinations. However, the neuronal and circuit mechanisms underlying the encoding of goal...
1 week ago

Dopaminergic neurodegeneration in Gerstmann–Sträussler–Scheinker (P102L) disease: insights from imaging and pathological examination

Frontiers
Gerstmann–Sträussler–Scheinker (GSS) disease is an inherited prion disease characterized by dementia, cerebellar ataxia, and painful sensory disturbances.
2 weeks ago

Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model

Nature
Calbindin is the marker that best identifies the most resilient neurons located in the dorsal tier and ventral tegmental area.
1 month ago

Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response | Cell Death & Disease

Nature
We provide evidence that microglia exhibit phagocytic activity towards both dead and stressed viable dopaminergic neurons through a galectin-3-dependent...
1 month ago

Buildup of fat-like lipids may drive nerve cell loss in Parkinson’s

Parkinson's News Today
Share this article: ... A scientist works with vials in a lab. A buildup of fat-like lipid molecules may help to promote the inability of dopaminergic neurons,...
1 month ago

Abatacept inhibits Th17 differentiation and mitigates α-synuclein-induced dopaminergic dysfunction in mice

Nature
Chronic treatment of mice with abatacept, a recombinant fusion protein that selectively modulates a co-stimulatory signal necessary for T-cell activation,...
1 month ago