Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in grafts containing...
10 months ago

In mice, dopamine release in the brain increased the abundance and activity of the enzyme neprilysin, which degraded amyloid-β specifically in the working...
2 months ago

Human midbrain organoid culture has become a widely adopted system for long-term maintenance of functionally mature midbrain dopaminergic neurons from stem...
10 months ago

Resource-seeking behaviours are ordinarily constrained by physiological needs and threats of danger, and the loss of these controls is associated with...
11 months ago

The cerebellum directly, rapidly and effectively modulates basal ganglia dopamine levels and conveys information related to movement initiation, vigor and...
8 months ago

We now report data demonstrating that disruption of USP30 in Usp30 KO mice stimulates mitophagy and results in highly significant protection against αSyn...
11 months ago

Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD), while those in the...
3 months ago

This study investigates the impact of aging in conjunction with overexpression of wild-type human α-synuclein (α-Syn) in the dopaminergic system.
8 months ago

Results · E326K-GBA1 mutant DA neurons exhibit reduced synaptic activity and a reduction in the sodium currents · ECM receptor interaction, focal-adhesion, and...
7 months ago

Here, we demonstrate that GUCY2C promotes mitochondrial function, reducing oxidative stress and protecting DA neurons from degeneration.
6 months ago