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Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Nature
Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of Parkinson's disease (PD) pathology, yet a cellular model for LB...
2 days ago
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Molecular Neurodegeneration
Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson's disease (PD). However, the mechanisms by which intracellular...
2 days ago
Soot nanoparticles promote ferroptosis in dopaminergic neurons via alteration of m6A RNA methylation in Parkinson’s disease
ScienceDirect.com
Soot nanoparticles (SNPs) are black carbon prevalent in atmospheric environment with significant impacts on public health, leading to neurodegenerative...
6 days ago
Replicating Lewy body formation in living neurons to understand Parkinson's disease
News-Medical
Lewy bodies are a hallmark of Parkinson's disease (PD) and other related neurological conditions. Understanding why and how they develop is critical to...
2 days ago
Immune Response Linked to Lewy Body Formation
Neuroscience News
New research reveals that immune responses play a crucial role in the formation of Lewy bodies, protein aggregates that mark Parkinson's disease and other...
2 days ago
New link found between immune system and neurological disease
Drug Target Review
Findings show that alpha-synuclein and an immune response are required for Lewy body formation, in an effect specific to dopaminergic neurons.
16 hours ago
Parkinson’s Lewy Bodies Formed in Human Neuronal Stem Cells
Genetic Engineering and Biotechnology News
Scientists used stem cells to recreate the growth of Lewy bodies in human neurons to gain insight into why and how they form.
2 days ago
Scientists recreated a hallmark of Parkinson’s disease in human neurons
Tech Explorist
Lewy bodies (LBs) are clumps of a protein called α-synuclein found in brain cells and are a vital feature of Parkinson's disease (PD).
2 days ago
Reactivating Spatial Memories with Light
Optics & Photonics News
Meeri Kim. Image of green and red from a light-sheet microscope of dopaminergic transmitter inputs. A light-sheet microscope 3D image displays the...
13 hours ago
Replicating Lewy body formation in living neurons to understand Parkinson's disease
MSN
Lewy bodies are a hallmark of Parkinson's disease (PD) and other related neurological conditions. Understanding why and how they develop is critical to...
2 days ago