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Behavioural and dopaminergic signatures of resilience

Nature
These data provide a link between DA neural activity, resilience and resilience-associated behaviour during the experience of stress.
23 months ago

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

Science | AAAS
In mice, dopamine release in the brain increased the abundance and activity of the enzyme neprilysin, which degraded amyloid-β specifically in the working...
2 months ago

A dopaminergic switch for fear to safety transitions

Nature
Overcoming aversive emotional memories requires neural systems that detect when fear responses are no longer appropriate so that they can be...
75 months ago

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

Nature
In a preclinical study, dopaminergic neurons derived from human induced pluripotent stem cells were implanted into a primate model of...
85 months ago

Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells

Nature
Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in...
10 months ago

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids

Nature
Human midbrain organoid culture has become a widely adopted system for long-term maintenance of functionally mature midbrain dopaminergic...
10 months ago

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Nature
Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson's...
51 months ago

Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure

Nature
Addictive substances are known to increase dopaminergic signaling in the mesocorticolimbic system. The origin of this dopamine (DA)...
103 months ago

Dopaminergic systems create reward seeking despite adverse consequences

Nature
Resource-seeking behaviours are ordinarily constrained by physiological needs and threats of danger, and the loss of these controls is...
11 months ago

A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

Nature
We combine quantitative epidemiologic study of pesticide exposures and PD with toxicity screening in dopaminergic neurons derived from PD patient induced...
16 months ago