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Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time

Nature
The dominant theoretical framework to account for reinforcement learning in the brain is temporal difference learning (TD) learning,...
3 months ago

Hemispheric differences in the mesostriatal dopaminergic system

Frontiers
The mesostriatal dopaminergic system, which comprises the mesolimbic and the nigrostriatal pathways, plays a major role in neural processing underlying...
3 months ago

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults | npj Parkinson's Disease

Nature
Here, we demonstrate that GUCY2C promotes mitochondrial function, reducing oxidative stress and protecting DA neurons from degeneration.
6 months ago

Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease

Frontiers
We review recent studies and provide new insight on the link between metabolic diseases and the degeneration of dopaminergic neurons, which consequently leads...
3 months ago

A feature-specific prediction error model explains dopaminergic heterogeneity

Nature
The hypothesis that midbrain dopamine (DA) neurons broadcast a reward prediction error (RPE) is among the great successes of computational...
3 months ago

Adult-onset deletion of ATP13A2 in mice induces progressive nigrostriatal pathway dopaminergic degeneration and lysosomal abnormalities

Nature
Although most cases of Parkinson's disease (PD) are sporadic, mutations in over 20 genes are known to cause heritable forms of the disease.
2 months ago

DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease | Cell Death & Disease

Nature
The loss of dopaminergic neurons in the substantia nigra is a hallmark of pathology in Parkinson's disease (PD).
4 months ago

Abatacept inhibits Th17 differentiation and mitigates α-synuclein-induced dopaminergic dysfunction in mice

Nature
Chronic treatment of mice with abatacept, a recombinant fusion protein that selectively modulates a co-stimulatory signal necessary for T-cell...
1 month ago

Dissociable effects of dopaminergic medications on depression symptom dimensions in Parkinson disease

Nature
We investigated whether there are dissociable effects of dopaminergic medications on different depression symptom dimensions in PD.
3 months ago

Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K- GBA1 Parkinson’s disease patients

Nature
Results · E326K-GBA1 mutant DA neurons exhibit reduced synaptic activity and a reduction in the sodium currents · ECM receptor interaction,...
7 months ago