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Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines

Nature
Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of Parkinson's disease (PD) pathology, yet a cellular model...
1 month ago

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

Science | AAAS
Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to cognitive decline in Alzheimer's disease (AD).
3 months ago

Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson’s Disease

Frontiers
Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson's Disease ... Motor symptoms in Parkinson's disease (PD) are...
5 months ago

α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

Molecular Neurodegeneration
Conclusions. Taken together, our findings suggest that disruption of mitochondrial function, and the subsequent bioenergetic deficit, is a...
1 month ago

A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

PNAS
Striatal acetylcholine and dopamine critically regulate movement, motivation, and reward-related learning. Pauses in cholinergic interneuron (CIN) firing are...
1 month ago

Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates

Nature
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD),...
5 months ago

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

Frontiers
In Parkinson's disease (PD), the motor manifestations are primarily linked to the selective, progressive loss of dopaminergic (DA) neurons in the substantia...
5 months ago

Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model

Nature
In conclusion, we have validated and expanded to the primate brain previous findings in Parkinson´s disease rodent models by describing in...
3 months ago

Dopaminergic Neuromodulation of Spike Timing Dependent Plasticity in Mature Adult Rodent and Human Cortical Neurons

Frontiers
Synapses in the cerebral cortex constantly change and this dynamic property regulated by the action of neuromodulators such as dopamine (DA), is essential for...
5 months ago

Molecular and cellular determinants of L-Dopa-induced dyskinesia in Parkinson’s Disease

Nature
Treatment with L-3,4-dihydroxyphenylalanine (L-Dopa) compensates for decreased striatal dopamine (DA) levels and reduces Parkinson's disease...
1 day ago