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AVE0991 ameliorates dopaminergic neuronal damage in Parkinson’s disease through HOTAIRM1/miR-223-3p/α-synuclein axis
Nature
Parkinson's disease (PD) is a prevalent type of neurodegenerative disorder. AVE0991, a non-peptide analogue of Ang-(1–7), by which the progression of PD has...
2 days ago
Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update
Frontiers
In Parkinson's disease (PD), the motor manifestations are primarily linked to the selective, progressive loss of dopaminergic (DA) neurons in the substantia...
4 months ago
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Molecular Neurodegeneration
Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson's disease (PD). However, the mechanisms by which...
4 weeks ago
Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Nature
Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of Parkinson's disease (PD) pathology, yet a cellular model...
4 weeks ago
Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson’s Disease
Frontiers
Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson's Disease ... Motor symptoms in Parkinson's disease (PD) are...
4 months ago
Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model
Nature
Aldh1a1+ neurons were the main population of vulnerable dopaminergic nigrostriatal-projecting neurons, while Aldh1a1- neurons giving rise to...
2 months ago
Hemispheric differences in the mesostriatal dopaminergic system
Frontiers
The mesostriatal dopaminergic system, which comprises the mesolimbic and the nigrostriatal pathways, plays a major role in neural processing underlying...
4 months ago
Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
Nature
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD),...
4 months ago
Editorial: Brain dopaminergic mechanisms
Frontiers
Dopamine release is spatiotemporally regulated by multiple mechanisms, including tonic and phasic, axonal and somatodendritic, somatic activity-driven and...
4 months ago
Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time
Nature
The dominant theoretical framework to account for reinforcement learning in the brain is temporal difference learning (TD) learning,...
3 months ago