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The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

Science | AAAS
In mice, dopamine release in the brain increased the abundance and activity of the enzyme neprilysin, which degraded amyloid-β specifically in the working...
5 months ago

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults | npj Parkinson's Disease

Nature
Here, we demonstrate that GUCY2C promotes mitochondrial function, reducing oxidative stress and protecting DA neurons from degeneration.
9 months ago

Molecular insights into PCB neurotoxicity: Comparing transcriptomic responses across dopaminergic neurons, population blood cells, and Parkinson's disease pathology

ScienceDirect.com
We utilized iPSC-derived dopaminergic neurons to model PCB-induced neurotoxicity in Parkinson's disease. •. We assessed transcriptomic changes in neurons...
9 months ago

A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

PNAS
Striatal acetylcholine and dopamine critically regulate movement, motivation, and reward-related learning. Pauses in cholinergic interneuron (CIN) firing are...
3 months ago

α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

Molecular Neurodegeneration
Our findings suggest that disruption of mitochondrial function, and the subsequent bioenergetic deficit, is a proximal step in the cascade of events induced by...
3 months ago

Early dopaminergic replacement treatment initiation benefits motor symptoms in patients with Parkinson's disease

Frontiers
These data in our study showed that early dopaminergic replacement treatment have played a positive role in PD patients.
8 months ago

Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates

Nature
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD), while those in the...
7 months ago

Soot nanoparticles promote ferroptosis in dopaminergic neurons via alteration of m6A RNA methylation in Parkinson’s disease

ScienceDirect.com
This study demonstrates that SNPs may exacerbate the onset and progression of PD by recruiting YTH domain-containing family protein 1 (YTHDF1) protein.
6 months ago

Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K- GBA1 Parkinson’s disease patients

Nature
Results · E326K-GBA1 mutant DA neurons exhibit reduced synaptic activity and a reduction in the sodium currents · ECM receptor interaction, focal-adhesion, and...
11 months ago

The cerebellum directly modulates the substantia nigra dopaminergic activity

Nature
The cerebellum directly, rapidly and effectively modulates basal ganglia dopamine levels and conveys information related to movement initiation, vigor and...
11 months ago