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Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson’s disease

Nature
Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects from...
2 weeks ago

The dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses

Frontiers
The lateral habenula (LHb) has been implicated in stress coping and autonomic control. The LHb regulates the midbrain system of monoamine neurotransmitters...
1 week ago

Caffeine's impact on brain's mesolimbic dopaminergic pathway could reduce alcohol's addictive effects

PsyPost
Researchers found that caffeine blocks alcohol's ability to increase dopamine in brain reward areas, potentially reducing alcohol's rewarding effects.
2 weeks ago

The dopaminergic basis of negative symptoms in schizophrenia: an addendum

Nature
We would like to address the results of two recent positron emission tomography (PET) imaging studies and discuss them in relation to our own findings [1].
2 weeks ago

Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases

Molecular Neurodegeneration
Nuclear pore complexes (NPCs) are embedded in the nuclear envelope and facilitate the exchange of macromolecules between the nucleus and cytoplasm in...
1 week ago

Cerevance Doses First Patient in Pivotal Phase 3 ARISE Trial of Solengepras for Treatment of Parkinson’s Disease

GlobeNewswire
Solengepras is a potentially first-in-class, oral, non-dopaminergic investigational therapy in development for Parkinson's diseaseARISE will evaluate the...
2 weeks ago

S.BIOMEDICS Investigational Cell Therapy for Parkinson’s Disease With TED-A9 Shows Positive Data at 12-months in Phase 1/2a Clinical Trial

Morningstar
S.BIOMEDICS Investigational Cell Therapy for Parkinson's Disease With TED-A9 Shows Positive Data at 12-months in Phase 1/2a Clinical Trial.
5 days ago

Caffeine’s impact on brain’s mesolimbic dopaminergic pathway could reduce alcohol’s addictive effects

MSN
Scientists have recently discovered that caffeine may counteract some of alcohol's effects on the brain's reward system, particularly by blocking certain...
1 week ago

Parkinson’s Paradox: When more dopamine means more tremor

EurekAlert!
Researchers from the Champalimaud Foundation shed light on the puzzling relationship between dopamine and rest tremor in Parkinson's disease, finding that...
2 weeks ago

Parkinson’s Symptom, Resting Tremor, Relates to Dopamine in Unexpected Way

Genetic Engineering and Biotechnology News
Study suggests that preserved dopamine in certain brain regions may actually contribute to tremor symptoms, challenging common beliefs.
2 weeks ago