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Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines

Nature
Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of Parkinson's disease (PD) pathology, yet a cellular model...
1 month ago

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

Science | AAAS
Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to cognitive decline in Alzheimer's disease (AD).
3 months ago

The dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses

Frontiers
The lateral habenula (LHb) has been implicated in stress coping and autonomic control. The LHb regulates the midbrain system of monoamine...
1 week ago

α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

Molecular Neurodegeneration
Our findings suggest that disruption of mitochondrial function, and the subsequent bioenergetic deficit, is a proximal step in the cascade of events induced by...
1 month ago

A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

PNAS
Striatal acetylcholine and dopamine critically regulate movement, motivation, and reward-related learning. Pauses in cholinergic interneuron (CIN) firing are...
1 month ago

Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates

Nature
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD),...
5 months ago

Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson’s Disease

Frontiers
Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson's Disease ... Motor symptoms in Parkinson's disease (PD) are...
5 months ago

Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model

Nature
Calbindin is the marker that best identifies the most resilient neurons located in the dorsal tier and ventral tegmental area.
3 months ago

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

Frontiers
This review provides an update on the molecular basis of the differential vulnerability of midbrain DA neurons in PD and highlights the most recent...
5 months ago

The dopaminergic basis of negative symptoms in schizophrenia: an addendum

Nature
We would like to address the results of two recent positron emission tomography (PET) imaging studies and discuss them in relation to our...
2 weeks ago