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Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells
Nature
Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in grafts containing...
10 months ago
Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines
Nature
In this study, we found that induced pluripotent stem cell (iPSC)-derived human dopaminergic (DA) neurons form LB-like inclusions after treatment with α-...
3 weeks ago
In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids
Nature
Human midbrain organoid culture has become a widely adopted system for long-term maintenance of functionally mature midbrain dopaminergic neurons from stem...
10 months ago
The cerebellum directly modulates the substantia nigra dopaminergic activity
Nature
The cerebellum directly, rapidly and effectively modulates basal ganglia dopamine levels and conveys information related to movement initiation, vigor and...
9 months ago
Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging
Nature
This study investigates the impact of aging in conjunction with overexpression of wild-type human α-synuclein (α-Syn) in the dopaminergic system.
9 months ago
Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K- GBA1 Parkinson’s disease patients
Nature
Results · E326K-GBA1 mutant DA neurons exhibit reduced synaptic activity and a reduction in the sodium currents · ECM receptor interaction, focal-adhesion, and...
8 months ago
GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults | npj Parkinson's Disease
Nature
Here, we demonstrate that GUCY2C promotes mitochondrial function, reducing oxidative stress and protecting DA neurons from degeneration.
6 months ago
Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model
Nature
We now report data demonstrating that disruption of USP30 in Usp30 KO mice stimulates mitophagy and results in highly significant protection against αSyn...
11 months ago
Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
Nature
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD), while those in the...
4 months ago
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo
Nature
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic projections.
11 months ago