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Molecular mechanism of choline and ethanolamine transport in humans

Nature
We show that FLVCR1 and FLVCR2 facilitate the transport of choline and ethanolamine across the plasma membrane, using a concentration-driven substrate...
3 months ago

Can a Nutrient Transporter Sneak Drugs into the Brain?

Columbia University Irving Medical Center
A new study has found that the FLVCR2 protein (colored portions in images above) is responsible for transporting choline, an important nutrient for brain...
4 months ago

Combining genomics and metabolism identifies long-sought mitochondrial choline transporter

Medical Xpress
The investigators used the new platform, called GeneMAP (Gene-Metabolite Association Prediction), to identify a gene necessary for mitochondrial choline...
2 months ago

Transport mechanism of presynaptic high-affinity choline uptake by CHT1

Nature
Choline is a vital nutrient and a precursor for the biosynthesis of essential metabolites, including acetylcholine (ACh),...
5 months ago

New Hope for Neurological Disorders: Scientists Have Discovered How an Essential Nutrient Enters the Brain

SciTechDaily
New research has uncovered how choline, an essential nutrient, is transported into the brain by a protein called FLVCR2, crossing the blood-brain barrier.
4 months ago

Researchers reveal dynamic structure of FLVCR proteins and their function in nutrient transport

Phys.org
The researchers have shown that the proteins transport the cellular building blocks choline and ethanolamine.
3 months ago

Metabolic Proteins “Deorphanized” with Gene-Metabolite Association Prediction Tool

Genetic Engineering and Biotechnology News
Researchers developed the GeneMap platform to discover functions for orphan metabolic transporters and enzymes.
2 months ago

Little-known brain protein may be key to treating Alzheimer’s and ageing

PsyPost
Researchers have discovered that the brain protein Mfsd7c plays a crucial role in exporting excess choline, challenging previous beliefs and...
3 months ago

Nutrient research reveals pathway for treating brain disorders

Institute for Molecular Bioscience - University of Queensland
IMB researchers have found how dietary choline travels through the blood-brain barrier - a discovery that could be used to help deliver...
4 months ago

Illuminating the cell nutrient transport system

NUS - National University of Singapore
NUS researchers discover the molecular mechanisms that transport micronutrients to our cells, setting the groundwork for new therapeutic approaches for...
3 months ago