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Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor

Nature
ρ-type γ-aminobutyric acid-A (GABAA) receptors are widely distributed in the retina and brain, and are potential drug targets for the...
1 day ago

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The Transmitter
Unlike traditional antidepressants, ketamine acts quickly to relieve depression symptoms, and its effects last long after the drug has...
3 days ago

Scans Show Brain's Estrogen Activity Changes During Menopause

WCM Newsroom
PET scans showing brain estrogen receptor (ER) density in a premenopausal (left) and a postmenopausal (right) woman.
2 months ago

Spatially and temporally distinct patterns of expression for VPS10P domain receptors in human cerebral organoids

Frontiers
Our studies uncovered spatial and temporal patterns of expression unique to individual receptor species in the human brain.
2 months ago

Rice researchers uncover surprising role of opioid receptors in gut development

Rice News
Contrary to previous assumptions, the researchers found that opioid receptors are not solely involved in pain perception and addiction but are...
3 months ago

Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis

Nature
Antibodies against N-methyl-d-aspartate receptors (NMDARs) are most frequently detected in persons with autoimmune encephalitis (AE) and...
4 days ago

A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site

Nature
Although aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high...
2 days ago

Allosteric inhibition of NMDA receptors by low dose ketamine

Nature
Ketamine, a general anesthetic, has rapid and sustained antidepressant effects when administered at lower doses.
2 days ago

Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells

Nature
Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of...
4 days ago

Cell swelling enhances ligand-driven β-adrenergic signaling

Nature
G protein-coupled receptors' conformational landscape can be affected by their local, microscopic interactions within the cell plasma membrane.
1 day ago