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Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis

Nature
B-cell-specific-Tlr9-deficient mice exhibited increased fat tissue inflammation, weight gain, and impaired glucose and insulin tolerance.
4 months ago

Your Diet Might Be Causing More Inflammation Than You Think—Here's What to Know

Health
A new study found that 57% of Americans eat diets that are considered pro-inflammatory. Experts recommend focusing on fruits, vegetables,...
6 days ago

The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis

JCI.org
NR4A2 increased susceptibility to excitotoxicity by stimulating continuous VGF secretion leading to glycolysis-dependent neuronal cell death.
2 months ago

Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy

Frontiers
In this review, we describe the updated principal cellular and molecular mechanisms of inflammation resolution and cancer immunity and discuss the pro-...
8 months ago

Foods that fight inflammation

Harvard Health
Pro-inflammatory foods include fried foods, sodas, refined carbohydrates, and red meat. Foods that fight inflammation include green...
6 months ago

Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis

Science | AAAS
We find that abnormal oxidative phosphorylation (OXPHOS) contributes to aberrant B cell pro-inflammatory cytokine responses in patients with MS...
5 months ago

How excess niacin may promote cardiovascular disease

National Institutes of Health (NIH) (.gov)
A metabolite of niacin (vitamin B3) was associated with elevated risk of heart attack and stroke, likely due to inflammation in arteries.
7 months ago

LncRNA MIAT suppresses inflammation in LPS-induced J774A.1 macrophages by promoting autophagy through miR-30a-5p/SOCS1 axi

Nature
Accumulated data implicate that long noncoding RNA (lncRNA) plays a pivotal role in rheumatoid arthritis (RA), potentially serving as a...
2 weeks ago

Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging

Nature
Here, we show that the stress-responsive kinase apoptosis signal-regulating kinase 1 (ASK1) promotes inflammation in senescence and aging. ASK1...
4 months ago

Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution

Nature
Many lung immune cells are known to respond to inhaled particulate matter. However, current known responses cannot explain how particles...
1 month ago