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Alpha-synuclein-induced nigrostriatal degeneration and pramipexole treatment disrupt frontostriatal plasticity

Nature
Parkinson's disease is characterized by the degeneration of substantia nigra pars compacta (SNc) dopaminergic neurons, leading to motor and...
20 hours ago

Editorial: Brain dopaminergic mechanisms

Frontiers
Dopamine release is spatiotemporally regulated by multiple mechanisms, including tonic and phasic, axonal and somatodendritic, somatic activity-driven and...
2 months ago

Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time

Nature
The dominant theoretical framework to account for reinforcement learning in the brain is temporal difference learning (TD) learning,...
1 month ago

Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease

Frontiers
We review recent studies and provide new insight on the link between metabolic diseases and the degeneration of dopaminergic neurons, which consequently leads...
2 months ago

Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model

Nature
The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta (SNc) is a critical and unresolved question in...
1 week ago

Hemispheric differences in the mesostriatal dopaminergic system

Frontiers
The mesostriatal dopaminergic system, which comprises the mesolimbic and the nigrostriatal pathways, plays a major role in neural processing underlying...
2 months ago

Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates

Nature
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD),...
2 months ago

The Dopaminergic System in the Aging Brain of Drosophila

Frontiers
Here we analyzed the DA system and motor behavior in aging Drosophila. DA neurons in the adult brain can be grouped into bilateral symmetric clusters.
7 months ago

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults | npj Parkinson's Disease

Nature
Here, we demonstrate that GUCY2C promotes mitochondrial function, reducing oxidative stress and protecting DA neurons from degeneration.
4 months ago

Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning

Frontiers
Previous evidence shows a reliable association between psychosis-prone (especially schizotypal) personality traits and performance on dopamine...
2 months ago