CN102665658B - Water in oil type cosmetic composition for improving skin - Google Patents
Water in oil type cosmetic composition for improving skin Download PDFInfo
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- CN102665658B CN102665658B CN201080053269.6A CN201080053269A CN102665658B CN 102665658 B CN102665658 B CN 102665658B CN 201080053269 A CN201080053269 A CN 201080053269A CN 102665658 B CN102665658 B CN 102665658B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The present invention relates to a water-in-oil type cosmetic composition, which improves the skin to be smooth and keeps the skin free from troubles, and more particularly to a water-in-oil cosmetic composition which has a short-term skin improvement effect, caused by a ceramide-like amino acid derivative and a stabilized papain enzyme, and a long-term skin improvement effect caused by a polysaccharide having a prebiotic effect of selectively controlling bacteria.
Description
Technical field
The present invention relates to a kind of water-in-oil type cosmetic compositions of skin to become smooth and can prevent skin problem of improving, and relate more specifically to a kind of short-term skin improvement effect that is produced by ceramide type amino acid derivativges (ceramide-like amino acid derivative) and stable papain (stabilized papain enzyme) that has, and the water-in-oil type cosmetic compositions of the long-term skin improvement effect that is produced by the polysaccharide of the prebiotic effect with Selective Control antibacterial (prebiotic effect).
Background technology
Horny layer is the outermost layer of skin, is made up of dead cell.Healthy skin has the update cycle about 28 days, during this period, sloughs old keratin and forms the new cell of one deck.But if (comprise aging, pressure, ultraviolet and environmental pollution) because inherent and extrinsic factor, this renewal becomes slowly, and unnecessary keratin can accumulate and not slough, and causes skin to become slightly thick, and the generation melanin pigmentation makes skin darkening.In addition, this also can cause the formation of acne and wrinkle.
Epidermis is the outermost layer of skin, is the organ that contacts and provide the protection barrier all the time with external environment.The skin barrier that is present in keratodermatitis helps to suppress the loss of power and water solution matter, and the protection human body is avoided the damage of extraneous and chemicals, and prevents antibacterial and virus infiltration skin (Feingold KR.Cosmet.Toilet.112:49-59,1997).Horny layer is made up of two parts: form the protein that cell is formed by dead angle matter; And be present in lipid (people such as Elias PM, Adv.Lipid Res.24:1-26,1991) between keratinocyte.Wherein, the lipid between keratinocyte is considered to bringing into play most important effect in safeguarding skin barrier.Lipid between described keratinocyte is the lipid mixture of ceramide, cholesterol, free fatty etc., and contains intercellular lamella (intercellular lamellae).Especially, the ceramide that accounts for epidermis hydrated lipidic thin film (hydrolipid film) 40-50% have comprise sphingol, amido link non--labyrinth of hydroxy acid (amide-linked non-hydroxy acid), 'alpha '-hydroxy acids, ω-hydroxy acid or ester bond fatty acid (ester-linked fatty acid), and be important (people such as Choi MJ in keeping hydrated lipidic thin film laminated structure by the polarity that these structural elements form, Am.J.Clin.Dermatol.6:215-223,2005).
The health skin surface is rich in the required nutrition of growth of microorganism, and therefore skin surface exists many antibacterials usually.These antibacterials are divided into the pathogenic bacterium that cause human body diseases substantially, as staphylococcus or streptococcus, and the non-pathogenic bacteria that can not cause disease.Non-pathogenic bacteria is also referred to as normal flora and is found on the normal skin.Non-pathogenic bacteria can be divided into two types: even even can not remove when skin applied friction or skin carried out partly sterilised live antibacterial for a long time, be temporary on the skin and by partly sterilised or apply the antibacterial of staying temporarily that friction is easy to remove.
Live in other pathogenic bacterium that cause disease when normal flora on the skin helps to suppress to enter skin usually.Therefore, it is very useful and be that human body is necessary to human body to live in normal flora on the skin.If if if the quantity of skin damage or non-pathogenic bacteria reduces or the quantity of pathogenic bacterium increases sharply, human body will produce disease.Therefore, it is believed that if control the antibacterial that lives on the skin to make the rate of rise of nonpathogenic normal flora be higher than the rate of rise of pathogenic bacterium, can improve skin.
Summary of the invention
Therefore, improve the material that skin becomes smooth and can prevent skin problem in order to seek, the present inventor has carried out repeatedly research.The result; the present inventor finds; with the ceramide type amino acid derivativges with papain capsule and polysaccharide use can provide improve keratodermatitis and the protection skin barrier direct effect; and can optionally reduce the antibacterial that the meeting that is present on the skin causes skin problem, thereby finish the present invention.
Therefore, the purpose of this invention is to provide a kind of skin that improves becomes smooth and water-in-oil type cosmetic compositions that can prevent skin problem.
To achieve these goals, the invention provides a kind of water-in-oil type cosmetic compositions that contains ceramide type amino acid derivativges, papain capsule and polysaccharide.
Water-in-oil type cosmetic compositions of the present invention contains buffer agent, has the structure similar to skin phospholipid in the foreign minister of described cosmetic composition, helps preserving moisture and the lipid components of stable quantity of skin lubrication thereby provide.In addition, cosmetic composition of the present invention contains the capsule by the protease acquisition of encapsulation molt, moult albumen, described capsule is applicable to cosmetics, therefore use back protease capsule not play a role immediately, but softening keratin and when cleaning cosmetic composition, remove unnecessary keratin in can the special time after use, thereby skin is polished.In addition, compare with useful normal flora, cosmetic composition of the present invention can optionally reduce the content of pathogenic bacterium, thereby long-term skin nursing effect is provided.At last, water-in-oil type cosmetic compositions of the present invention makes skin not have keratin also moistening smooth and can prevent skin problem, is easy to make up thereby promote skin to become.
Description of drawings
Fig. 1 is one group and has shown the photo of measuring cosmetic composition preparation stability result;
Fig. 2 has shown that measuring cosmetic composition of the present invention is moisturizing content and reduce the result of the effect of keratin amount;
Fig. 3 is one group and has shown to measure and use behind the cosmetic composition of the present invention the result's of keratin amount photo on each time point skin;
Figure 4 and 5 are for having shown figure and the photo that utilizes image analyzer to measure face's surface imperfection degree (irregularity) result.
The specific embodiment
The invention provides a kind of water-in-oil type cosmetic compositions that contains ceramide type amino acid derivativges, papain capsule and polysaccharide.
Hereinafter, the present invention will be described in further detail.
The described ceramide type amino acid derivativges that is used as active component in the cosmetic composition of the present invention is plant sterol/behenyl alcohol/octyl group decanol lauroyl glutamate (phytosteryl/behenyl/octyldodecyl/lauroyl glutamate), described plant sterol/behenyl alcohol/octyl group decanol lauroyl glutamate is the emollient derived from glutamic acid, and is the paste material.It helps to prevent the water loss of skin and makes skin form the protection barrier of environment to external world.Described ceramide type amino acid derivativges dissolving also is scattered in the oil phase of described water-in-oil type cosmetic compositions.
Being used for described ceramide type amino acid derivativges of the present invention can make according to any conventional method known in the art, and preparation method is not particularly limited.For example, can utilize natural acid, higher alcohol and plant sterol to synthesize described ceramide type amino acid derivativges.
Gross weight with described compositions is benchmark, and the content that is used for described ceramide type amino acid derivativges of the present invention is 0.1-5.0 weight %.If the content of described ceramide type amino acid derivativges is lower than 0.1 weight %, the moisturizing effects of ceramide is very little, and if content be higher than 5 weight %, will make described compositions become sticky, make cosmetics use sense poor.
The described papain that is used as active component in the cosmetic composition of the present invention is the fruit juice of fruit Fructus Caricae and is a kind of protease.Known this protease helps treatment and the blood circulation promoting of inflammation and has cleaning skin or remove keratic effect under the situation that does not produce skin irritation.
Normally, contain multiple oiliness composition in the cosmetic formulations, described oiliness composition with emulsifying agent can destructive enzyme three dimensional structure because can be with the enzyme direct activation, the technology that can introduce cosmetic formulations to enzyme be essential.In the present invention, the papain capsule makes by the encapsulation papain, and the capsule that makes is added into the oil phase of described Water-In-Oil cosmetic composition and is dispersed in the preparation.
Being used for described papain capsule of the present invention can make according to any conventional method known in the art, and preparation method is not particularly limited.For example, described papain capsule can be by under papain stable p H, preparation contains the papain solution of papain and stabilizing agent, described papain solution and the liposome that comprises lecithin are formed composition mix, and mixture is made by high pressure homogenisers.
Gross weight with described compositions is benchmark, and the content of described papain capsule is 0.1-2.0 weight %.If the content of described papain capsule is lower than 0.1 weight %, its except the keratin effect very little, and if content be higher than 2.0 weight %, can make the use sense difference of cosmetics in use and cause skin irritation.
The described polysaccharide that is used as active component in the cosmetic composition of the present invention has the prebiotic effect of anti-staphylococcus epidermidis (Staphylococcus epidermidis) and propionibacterium acnes (Propionibacterium acnes).
Can be used for polysaccharide of the present invention for being selected from one or more of the group formed by Herba Orostachyos Flos Camelliae Japonicae (Orostachys japonicas) polysaccharide, green tea polysaccharide and Herba Artemisiae Scopariae (Artemisia capillaries) polysaccharide.
Being used for polysaccharide of the present invention can make according to any conventional method known in the art, and preparation method is not particularly limited.For example, described polysaccharide can make in such a way.With Herba Orostachyos Flos Camelliae Japonicae polysaccharide, green tea polysaccharide or the crushing of Herba Artemisiae Scopariae polysaccharide, add pure water, and at 95 ℃ of following heating extraction 3h.The extract that obtains successively through 250 holes, the filter of 3 μ m, 1 μ m and 0.5 μ m filters, and by being heated to 60 ℃ filtrate concentrated, and uses 95% ethanol precipitation then.Precipitate is centrifugal, and the precipitate that obtains is dissolved in the pure water.Solution filters through the filter of 0.5 μ m and 0.2 μ m successively, and vacuum drying filtrate, thereby obtains polysaccharide.
Gross weight with described compositions is benchmark, and the content that is used for described polysaccharide of the present invention is 0.0001-1.0 weight %.If the content of described polysaccharide is lower than 0.0001 weight %, can not obtain desired effects, and if content be higher than 1.0 weight %, can cause skin irritation.
Cosmetic composition of the present invention can be made the form of making up foremilk, foundation cream, facial cream, emulsion or concealer, but the preparation of described cosmetic composition is not particularly limited.
Hereinafter, will with test case the present invention be described in further detail in conjunction with the embodiments, but scope of the present invention is not limited in these embodiment.
Preparation example 1: the ceramide material of dissolving
Pure water, emulsifying agent, solubilizing agent and ceramide combination are made the ceramide material of dissolving.Herein, the amount of described ceramide dissolving is 3-5 weight %.
Preparation example 2: the ceramide material of encapsulation
Liposome technology (Lipid technology) is the key of the cosmetic product of research and development and skin function coordination.Prepare different encapsulating materials by the accurate simulation of liposome structure in the skin and the effective supply of active component.Utilize multicoating technology (multilayer coating process) and fluidization (fluidized bed technique), obtain intercellular lamella and liposomal body (lipid envelops) simultaneously.
Utilize ceramide material and the last process after preparation emulsifying of the described encapsulation that the multicoating prepared is made up of ceramide, lecithin and fatty acid to add.Carry out the stabilisation of capsule and softening process (at 45 ℃ of following 3h) with the foreign body sensation of the ceramide material that reduces encapsulation.For the impurity content that reduces described capsule also allows to make capsule break naturally in the described capsule of oil infiltration and carry out softening process.The advantage that the ceramide material of described encapsulation has is: be easier to introduce in the Water-In-Oil preparation and can strengthen the moisturizing activity with respect to traditional solubilizing agent.
Embodiment 1 and 2 and Comparative Examples 1-3
According to composition and the content that following table 1 shows, preparation embodiment 1 and 2 and preparation (the unit: weight %) of Comparative Examples 1-3.In the table 1, described ceramide type amino acid derivativges is plant sterol/behenyl alcohol/octyl group decanol lauroyl glutamate (CAS 245443-09-8; Purchase the company limited in Ajinomoto).
Table 1
The preparation method of＜embodiment 1 and 2 preparation 〉
1) the ceramide type amino acid derivativges is added in oil-phase component and the emulsifying agent, and make the mixture dissolving by being heated to 50-60 ℃.Then toward wherein adding and dispersion flows controlling agent, pigment and papain capsule, thereby make outer oil phase.
2) water-phase component that comprises pure water and polyhydric alcohol mixes mutually in independent container, thereby makes interior water.
3) with 2) interior water be added into 1) outer oil phase in, thereby obtain the Water-In-Oil preparation.
The preparation method of the preparation of＜Comparative Examples 1 〉
1) by being heated to 50-60 ℃ of dissolved oil phase constituent and emulsifying agent, then toward wherein adding and dispersion flows controlling agent and pigment, thereby makes outer oil phase.
2) water-phase component that comprises pure water and polyhydric alcohol mixes mutually in independent container, then toward wherein adding the ceramide material of dissolving, thereby makes interior water.
3) with 2) interior water be added into 1) outer oil phase in, thereby obtain the Water-In-Oil preparation.
The preparation method of the preparation of＜Comparative Examples 2 〉
1) by being heated to 50-60 ℃ of dissolved oil phase constituent and emulsifying agent, then toward wherein adding and dispersion flows controlling agent and pigment, thereby makes outer oil phase.
2) water-phase component that will comprise pure water and polyhydric alcohol mixes mutually, thereby makes interior water.
3) with 2) interior water be added into 1) outer oil phase in, thereby obtain the Water-In-Oil preparation.
4) with the encapsulation the ceramide material be added into 3) the Water-In-Oil preparation in and utilize the Agi-blender that it is uniformly dispersed.
Test case 1: according to the evaluation of the Water-In-Oil preparation of ceramide kind
In order to estimate stability of formulation according to the kind of ceramide, in thermostatic chamber, measure embodiment 1 and 2 and the thermostability of the preparation of Comparative Examples 1-3 and the greenhouse that changes in the cycle in measure stability according to variations in temperature.Same time of every day in room temperature, 30 ℃, 45 ℃ and 55 ℃ of thermostabilitys of measuring down in thermostatic chamber, and to stablize 7 days as standard.In the stability of measuring under the vibration condition of 170rpm in the cycle chamber 7 days, be benchmark with a circulation/sky, under-10 ℃, 30 ℃ and 45 ℃, keep each sample 7h respectively, the variations in temperature stage, (temperature change stage) was 1h.The result who measures is as shown in table 2 below.
In 7 days, altogether by from observing 5 definite preparation stabilities of stability of emulsion and pigment dispersibility in appearance.Estimate based on following standard: O=5 observation all is stable; Δ=3-4 observation is stable; And X=2 following the observation is stable.
Table 2
| Stability | Embodiment 1 | Embodiment 2 | Comparative Examples 1 | Comparative Examples 2 | Comparative Examples 3 |
| Stability of emulsion | O | O | X | Δ | O |
| The pigment dispersibility | O | O | Δ | X | O |
As can be seen, the oil phase material except ceramide type amino acid derivativges material has bad stability from Fig. 1 and table 2.As can be seen, contain the preparation of Comparative Examples 1 of the ceramide material of dissolving, oil separates with preparation gradually in the several hrs after the emulsifying.In addition, the preparation that contains the Comparative Examples 2 of ceramide capsule material exists and not to be transferred to before the consumer described capsule in the problem of 55 ℃ of following swelling fractures.In addition, about Comparative Examples 2, unlike basic product, when described capsule is dispersed in the described preparation, can opaque layer occur and produce foreign body sensation.On the other hand, the ceramide type amino acid derivativges can add with the form of pasty state in the described oil-phase component, thereby can add in the described preparation easily and do not influence preparation stability, has shown that the preparation of embodiment 1 and 2 has good stable.
Test case 2: the clinical trial of skin moisturizing activity and keratin amount
In order to confirm to improve the effect that skin becomes smooth, preparation is used skin moisturizing activity and the keratin amount of the preparation of front and back embodiment 2 carry out clinical measurement.Measured for 2 weeks on one's body 10 people altogether.The papain that uses in this test is purchased the company limited in AT Lab..
Particularly, after washing face, allow the experimenter in thermostatic constant wet chamber, adapt to the constant temperature and humidity condition (temperature: 22 ± 2 ℃, relative humidity: 40 ± 2%) 15min, gather the face's optical photograph that uses preparation preceding then, measure water content, keratin amount and skin surface roughness before preparation uses.After the experimenter uses preparation and adapts to constant temperature and humidity condition 15min, measure above-mentioned several again.Use every day preparation after the week and two weeks once, measure above-mentioned several again.After the measurement, determine with respect to the significant difference (paired t-test, P＜0.05) that uses the value that obtains before the preparation.In addition, utilize image analyzer to measure the degree of irregularity on face surface.Measurement result is shown in Fig. 2-5.
From Fig. 2-5 as can be seen, when when skin uses cosmetic composition of the present invention, increasing the skin water content, reduce keratin amount and skin surface roughness, thereby make skin smooth moistening.
Test case 3: the test of giving birth to the water bag water formulation effect of amount according to benefit
Prebiotic substance is water-soluble material, and the foreign minister is water in the oil-in-water preparation, makes active component and contact skin.Therefore, the effect of preparation can be shifted, and during in-vitro measurements, the active component of the aqueous phase that is easy to take a sample.On the other hand, about the Water-In-Oil preparation of describing among the present invention, described water is present in the described inner phase, thereby is difficult to the effect of the described preparation of prediction.For this reason, carry out test according to the Water-In-Oil preparation effect of prebiotic substance content.Preparation contains the Comparative Examples 4 of the compositions that shows in the following table 3 and the base formulation of embodiment 3-5 respectively.Polysaccharide is added into the water portion of base formulation herein, with the amount of 0,2,0.1 and 0.005 weight %.For the polysaccharide of described prebiotic substance obtains from weight ratio is green tea, Herba Artemisiae Scopariae and the Herba Orostachyos Flos Camelliae Japonicae polysaccharide of 60: 30: 10 weight %, and polysaccharide used herein is purchased the company limited in Korea S Bio-Land respectively.
Table 3
The preparation method of the preparation of＜embodiment 3-5 and Comparative Examples 4 〉
1) the ceramide type amino acid derivativges is added in oil-phase component and the emulsifying agent, and makes the mixture dissolving by being heated to 50-60 ℃.Then, past wherein the adding and dispersion flows controlling agent, pigment and papain capsule, thus make outer oil phase.
2) water-phase component that comprises pure water and polyhydric alcohol and prebiotic substance mixes mutually in independent container, thereby makes interior water.
3) with 2) interior water be added into 1) outer oil phase in, thereby obtain the Water-In-Oil preparation.
In test, prepare the Water-In-Oil basis preparation of embodiment 3-5 and Comparative Examples 4 respectively as mentioned above, dilution is 10 times in distilled water.Diluent stores 5min in 50 ℃ of water-baths, vortex (vortexed) is 5 times then, each 1min.By filter paper filtering vortex solution, filter by 0.2 μ m filter then, thereby make sample filtrate.
＜bacterial cell method of counting 〉
1. dissolve pretreated sample filtrate toward the peptone that wherein adds 1 weight % respectively, by 0.2 μ m filter paper sample solution is sterilized then.
2. the test bacterial solution of inoculation 10 μ l/ml in the sample solution of each sterilization is determined initial cell quantity then.(herein, water suitably dilutes described bacterial solution, then the diluent of 1ml is applied to the surface of culture medium, and calculates the quantity of bacterial cell by final clump count and extension rate are multiplied each other).
3. every kind of sample solution will having inoculated bacterial solution is cultivated 1 day (situation of propionibacterium acnes) in 32 ℃ of following shaken cultivation 1 day (situation of staphylococcus epidermidis) with 35 ℃ of following anaerobism respectively.
4. suitably dilute the bacterial solution of cultivating respectively, and get the diluent of 1ml.The diluent of staphylococcus epidermidis is coated on the TS agar, coated on the BHI agar and 35 ℃ of following anaerobism then 35 ℃ of following cultivations 1 day, and with the diluent of propionibacterium acnes and cultivated 3 days.Then, measure cell quantity in each bacterial solution.
Measure the quantity of bacterial cell according to above-mentioned count of bacteria method, and calculate the rate of rise of bacterial cell quantity in each sample according to following formula 1.Result of calculation is as shown in table 4 below.
[formula 1]
The quantity of bacterial cell in the blank behind the quantity/0h of bacterial cell in the blank behind the quantity ÷ 24h of bacterial cell in the sample behind the quantity/0h of bacterial cell in the sample behind the rate of rise=24h of bacterial cell quantity in the sample
Calculate the K value of the rate of rise that is used for the staphylococcic rate of rise of comparative sample mesocuticle and sample propionibacterium acnes according to following formula 2.High K value shows relative the increasing of rate of rise of beneficial bacteria and has given prebiotic effect.
[formula 2]
The rate of rise of propionibacterium acnes in the staphylococcic rate of rise/sample of K=sample mesocuticle
Table 4
As can be seen from Table 4, the polysaccharide in the embodiment 3-5 preparation has prebiotic effect, and when having diluted 10 times in the consideration pre-treatment step, similarly surpasses content range 0.2-0.0005 weight % basically.Therefore, can find, even when only being added into polysaccharide in the water-in-oil type cosmetic compositions with the amount of 0.0005 weight %, also can show prebiotic effect.
Therefore, Water-In-Oil cosmetic composition of the present invention has good prebiotic effect, thereby can optionally reduce the content of pathogenic bacterium with respect to useful normal flora.Therefore, it can suppress skin problem and have long-term skin nursing effect.
Though the embodiment in conjunction with specific description has been described the present invention, the present invention is not limited to embodiment and claims of only limiting to enclose.Be understandable that under the situation that does not depart from the scope of the invention and spirit, those skilled in the art can change or modify these embodiments.
Claims (5)
1. water-in-oil type cosmetic compositions that contains ceramide type amino acid derivativges, papain capsule and polysaccharide; Described ceramide type amino acid derivativges is plant sterol/behenyl alcohol/octyl group decanol lauroyl glutamate.
2. water-in-oil type cosmetic compositions according to claim 1 wherein, is benchmark with the gross weight of described compositions, and the content of described ceramide type amino acid derivativges is 0.1-5.0 weight %.
3. water-in-oil type cosmetic compositions according to claim 1 wherein, is benchmark with the gross weight of described compositions, and the content of described papain capsule is 0.1-2.0 weight %.
4. water-in-oil type cosmetic compositions according to claim 1, wherein, described polysaccharide is for being selected from least a in the group of being made up of Herba Orostachyos Flos Camelliae Japonicae (Orostachys japonicas) polysaccharide, green tea polysaccharide and Herba Artemisiae Scopariae (Artemisia capillaries) polysaccharide.
5. water-in-oil type cosmetic compositions according to claim 1 wherein, is benchmark with the gross weight of described compositions, and the content of described polysaccharide is 0.0001-1.0 weight %.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2009-0116446 | 2009-11-30 | ||
| KR1020090116446A KR101640857B1 (en) | 2009-11-30 | 2009-11-30 | Water in Oil type make-up cosmetic composition for improving skin |
| PCT/KR2010/008428 WO2011065772A2 (en) | 2009-11-30 | 2010-11-26 | Water in oil type cosmetic composition for improving skin |
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| CN102665658A CN102665658A (en) | 2012-09-12 |
| CN102665658B true CN102665658B (en) | 2013-09-25 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013070891A1 (en) | 2011-11-08 | 2013-05-16 | The Procter & Gamble Company | Method of identifying prebiotics and compositions containing the same |
| CA2863681A1 (en) * | 2012-02-14 | 2013-08-22 | The Procter & Gamble Company | Topical use of a skin-commensal prebiotic agent and compositions containing the same |
| JP5690779B2 (en) * | 2012-07-10 | 2015-03-25 | 株式会社 資生堂 | Water-in-oil emulsified cosmetic |
| CN105640819A (en) * | 2014-11-13 | 2016-06-08 | 广州十长生化妆品有限公司 | Skin tendering smoothening whitening exfoliating microsphere and application thereof |
| KR101908347B1 (en) * | 2014-12-31 | 2018-10-17 | (주)아모레퍼시픽 | Chemically anisotropic particles and w/o emulsion composition comprising the same |
| KR102506973B1 (en) | 2015-09-02 | 2023-03-07 | (주)아모레퍼시픽 | High internal phase Water-in-Oil type emulsified cosmetic composition |
| CA3018865A1 (en) | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| CA3018866C (en) | 2016-03-31 | 2024-03-26 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| AU2017365019A1 (en) | 2016-11-23 | 2019-07-11 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| CN107007492B (en) * | 2016-12-26 | 2018-03-09 | 广州市花安堂生物科技有限公司 | A kind of makeup remover and preparation method thereof |
| CN111675770B (en) * | 2020-07-15 | 2022-03-15 | 延边大学 | Preparation method and application of orostachys wolfsii polysaccharide |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20110059986A (en) | 2011-06-08 |
| WO2011065772A2 (en) | 2011-06-03 |
| WO2011065772A3 (en) | 2011-11-17 |
| KR101640857B1 (en) | 2016-08-01 |
| CN102665658A (en) | 2012-09-12 |
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