CA2166006A1 - Noninvasive Method and Apparatus for Determining Body Chemistry - Google Patents

Noninvasive Method and Apparatus for Determining Body Chemistry

Info

Publication number
CA2166006A1
CA2166006A1 CA2166006A CA2166006A CA2166006A1 CA 2166006 A1 CA2166006 A1 CA 2166006A1 CA 2166006 A CA2166006 A CA 2166006A CA 2166006 A CA2166006 A CA 2166006A CA 2166006 A1 CA2166006 A1 CA 2166006A1
Authority
CA
Canada
Prior art keywords
eye
response
light
chemistry
body chemistry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2166006A
Other languages
French (fr)
Other versions
CA2166006C (en
Inventor
Michael E. Barkenhagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Raytheon Co
Original Assignee
Hughes Aircraft Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hughes Aircraft Co filed Critical Hughes Aircraft Co
Publication of CA2166006A1 publication Critical patent/CA2166006A1/en
Application granted granted Critical
Publication of CA2166006C publication Critical patent/CA2166006C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Abstract

The body chemistry of a person is determined by directing a beam of light into the eye (28) of the person, measuring the spectral response of the eye to the beam of light, comparing the measured spectral response to a standard spectral response, and forming a conclusion as to the chemistry of the body from the comparison. The light selected for the measurement does not harm the eye (28), and is preferably in the ultraviolet or infrared ranges.
The response of the eye (28) chosen for measurement is that of reflected, fluoresced, or scattered light. It is preferred to use two or more of these techniques simultaneously, to minimize the likelihood of error. The comparison is made by comparing the measured response of the eye (28) to a standard response from a library of previously established responses.
CA002166006A 1995-01-20 1995-12-22 Noninvasive method and apparatus for determining body chemistry Expired - Fee Related CA2166006C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/375,742 1995-01-20
US08/375,742 US5553617A (en) 1995-01-20 1995-01-20 Noninvasive method and apparatus for determining body chemistry

Publications (2)

Publication Number Publication Date
CA2166006A1 true CA2166006A1 (en) 1996-07-21
CA2166006C CA2166006C (en) 1999-11-23

Family

ID=23482142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002166006A Expired - Fee Related CA2166006C (en) 1995-01-20 1995-12-22 Noninvasive method and apparatus for determining body chemistry

Country Status (4)

Country Link
US (1) US5553617A (en)
EP (1) EP0722692A1 (en)
JP (1) JP3129956B2 (en)
CA (1) CA2166006C (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3592416B2 (en) * 1995-10-31 2004-11-24 晃敏 吉田 Measuring device for intraocular substances
US5882301A (en) * 1995-12-13 1999-03-16 Yoshida; Akitoshi Measuring apparatus for intraocular substance employing light from eyeball
JP3604231B2 (en) * 1996-05-16 2004-12-22 富士写真フイルム株式会社 Method and apparatus for measuring glucose concentration
US5873831A (en) * 1997-03-13 1999-02-23 The University Of Utah Technology Transfer Office Method and system for measurement of macular carotenoid levels
EP1037553B1 (en) * 1997-11-12 2007-01-24 Lightouch Medical, Inc. Method for non-invasive measurement of an analyte
US5919132A (en) * 1998-03-26 1999-07-06 Universite De Montreal On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye
US6149589A (en) * 1998-03-26 2000-11-21 Universite De Montreal On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye
AU4970499A (en) 1998-07-07 2000-01-24 Lightouch Medical, Inc. Tissue modulation process for quantitative noninvasive in vivo spectroscopic analysis of tissues
US6574501B2 (en) 1998-07-13 2003-06-03 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances or toxins in a subject by analyzing Raman spectrum signals of selected regions in the eye
US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
AU4986899A (en) 1998-07-13 2000-02-01 Children's Hospital Of Los Angeles Non-invasive glucose monitor
JP2000037355A (en) * 1998-07-24 2000-02-08 Fuji Photo Film Co Ltd Method for measuring glucose concentration and apparatus therefor
US6853854B1 (en) 1998-09-18 2005-02-08 Q Step Technologies, Llc Noninvasive measurement system
AU6153699A (en) * 1998-09-18 2000-04-10 Walter K. Proniewicz Noninvasive measurement of blood sugar based on optoelectronic observations of the eye
US6721583B1 (en) * 1998-11-19 2004-04-13 The United States Of America Method for non-invasive identification of individuals at risk for diabetes
US6205354B1 (en) 1999-06-18 2001-03-20 University Of Utah Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue
AU3213500A (en) * 1999-09-17 2001-04-24 Walter K. Proniewicz Noninvasive measurement of blood sugar level
US6961599B2 (en) * 2001-01-09 2005-11-01 Childrens Hospital Los Angeles Identifying or measuring selected substances or toxins in a subject using resonant raman signals
WO2002069789A1 (en) * 2001-03-01 2002-09-12 University Of Massachusetts Ocular spectrometer and probe method for non-invasive spectral measurement
GB2373044B (en) 2001-03-09 2005-03-23 Chris Glynn Non-invasive spectrophotometer
DE10129754A1 (en) * 2001-06-20 2003-01-02 Holger Jungmann Detection of the presence of substances in vital tissue materials by passing light of a given wavelength through the material for its intensity to be compared with a reference system
US6650915B2 (en) * 2001-09-13 2003-11-18 Fovioptics, Inc. Non-invasive measurement of blood analytes using photodynamics
US20050010091A1 (en) * 2003-06-10 2005-01-13 Woods Joe W. Non-invasive measurement of blood glucose using retinal imaging
US7039452B2 (en) 2002-12-19 2006-05-02 The University Of Utah Research Foundation Method and apparatus for Raman imaging of macular pigments
US6895264B2 (en) * 2002-08-26 2005-05-17 Fovioptics Inc. Non-invasive psychophysical measurement of glucose using photodynamics
US20040254479A1 (en) 2003-02-20 2004-12-16 John Fralick Bio-photonic feedback control software and database
GB2407378B (en) 2003-10-24 2006-09-06 Lein Applied Diagnostics Ltd Ocular property measuring apparatus and method therefor
GB2409033C (en) * 2003-12-12 2006-05-24 Lein Applied Diagnostics Ltd Extended focal region measuring apparatus and method
US20050278184A1 (en) 2004-06-10 2005-12-15 John Fralick Bio-photonic feedback control software and database
WO2006000911A1 (en) * 2004-06-23 2006-01-05 Alec Blanchard Blood and tissue component analysis apparatus
US7537111B2 (en) * 2004-09-10 2009-05-26 Pactech Investments, Llc Paint paraphernalia method and apparatus
US7365839B2 (en) 2004-11-03 2008-04-29 Nu Skin International, Inc. Process and compositions for synthetic calibration of bio-photonic scanners
US7330746B2 (en) * 2005-06-07 2008-02-12 Chem Image Corporation Non-invasive biochemical analysis
US7330747B2 (en) * 2005-06-07 2008-02-12 Chemimage Corporation Invasive chemometry
US8554296B2 (en) 2005-10-14 2013-10-08 Gholam A. Peyman Photoacoustic measurement of analyte concentration in the eye
US20070088206A1 (en) * 2005-10-14 2007-04-19 Peyman Gholam A Photoacoustic measurement of analyte concentration in the eye
DE102007003341B4 (en) 2007-01-17 2018-01-04 Eyesense Ag Eyepiece sensor and measuring system for detecting an analyte in an eye fluid
GB2451443B (en) 2007-07-30 2012-12-26 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
GB2457302B (en) 2008-02-11 2013-04-10 Lein Applied Diagnostics Ltd Measurement apparatus and method therefor
EP2459053A2 (en) 2009-07-28 2012-06-06 F. Hoffmann-La Roche AG Non-invasive in vivo optical imaging method
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
JP6071082B2 (en) * 2015-04-23 2017-02-01 鈴木　英雄 Processing method and product for three-dimensional recognition of planar image
WO2017108869A1 (en) * 2015-12-21 2017-06-29 Koninklijke Philips N.V. Device for tissue condition measurement
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963019A (en) * 1974-11-25 1976-06-15 Quandt Robert S Ocular testing method and apparatus
US4412543A (en) * 1981-04-09 1983-11-01 Xanar, Inc. Apparatus for determining the concentration of a fluorescent material in an eye
US4569354A (en) * 1982-03-22 1986-02-11 Boston University Method and apparatus for measuring natural retinal fluorescence
US4811739A (en) * 1982-09-03 1989-03-14 Silver Robert H Method and apparatus for the determination of substances in human fluids
US5207668A (en) * 1983-11-17 1993-05-04 Visx Incorporated Method for opthalmological surgery
US4836207A (en) * 1987-09-09 1989-06-06 The Beth Israel Hospital Association Method and apparatus to monitor cholesterol levels with photon correlation spectroscopy
US5361758A (en) * 1988-06-09 1994-11-08 Cme Telemetrix Inc. Method and device for measuring concentration levels of blood constituents non-invasively
GB8909491D0 (en) * 1989-04-26 1989-06-14 Glynn Christopher J Device for real-time monitoring of human or animal bodily functions
US5048946A (en) * 1990-05-15 1991-09-17 Phoenix Laser Systems, Inc. Spectral division of reflected light in complex optical diagnostic and therapeutic systems
US5243983A (en) * 1990-12-14 1993-09-14 Georgia Tech Research Corporation Non-invasive blood glucose measurement system and method using stimulated raman spectroscopy
JPH04352933A (en) * 1991-05-29 1992-12-08 Kowa Co Opthalmic measuring method
US5323775A (en) * 1991-09-13 1994-06-28 Allergan, Inc. Diagnostic method for determining precorneal retention time of ophthalmic formulations
JPH07508426A (en) * 1991-10-17 1995-09-21 サイエンティフィック　ジェネリクス　リミテッド Blood sample measuring device and method
US5433197A (en) * 1992-09-04 1995-07-18 Stark; Edward W. Non-invasive glucose measurement method and apparatus
DE4243142A1 (en) * 1992-12-19 1994-06-23 Boehringer Mannheim Gmbh Device for in-vivo determination of an optical property of the aqueous humor of the eye

Also Published As

Publication number Publication date
EP0722692A1 (en) 1996-07-24
US5553617A (en) 1996-09-10
JP3129956B2 (en) 2001-01-31
JPH08238221A (en) 1996-09-17
CA2166006C (en) 1999-11-23

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Effective date: 20121224