The first women's Manchester derby will be held at the Etihad as Manchester City host Manchester United in the first game of the new Women's Super League season.
The club confirmed the first women's derby will be played on the opening day of the season on September 7 at 3pm in the curtain-raiser for the new campaign.
Nick Cushing's side will face newly-promoted Championship champions Manchester United , who won the title by nine points last season in their inaugural campaign, and will be the second fixture played by City's women's side at the Etihad.
The Blues played Everton there back in 2014 but, they only drew a crowd of 1,462 and they'll be hoping to build on that, especially given the popularity of this summer's World Cup.
This summer's tournament broke records with 11.7m tuning in to watch England's semi-final loss to the USA and Kelly Simmons, the Football Association's director of the professional game, wants to build on that momentum.
"Our job now is to make sure we capitalise on the momentum from the Women's World Cup and build audiences and build attendances," she told The BBC.
"I think one of the things the World Cup has done has made our players household names, and now people can follow them back at their clubs.
"We know there's a massive potential audience of fans coming across from the men's game and the men's clubs. We're seeing very much this 'one club ethos'.
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"There's a massive chance for the game to pull those across this season with the Women's Super League and get more people coming to games and watching games on television.
"The stand-alone games in the men's stadiums, we've already seen when we've done that before a big uplift in numbers coming to the games."
City and England captain Steph Houghton is already looking forward to the occasion:“We are all very excited to play our first home game of the season at the Etihad Stadium and, better yet, in a Manchester Derby.
"Big games like this are the ones you want to be in as a player and every one of us Manchester City players is looking forward to getting on that pitch and giving you all a performance to be proud of.”
Casey Stoney's side were only established last summer and have yet to play at Old Trafford however, M.E.N. Sport understands the club are discussing the possibility of a game there next season.
England manager Phil Neville called upon clubs to hold games at big stadiums in order to try and grow the game.
“What I would say is now there are some teams, the big teams, who have got to open their big stadiums and fill it. Let’s blow the rest of Europe away because I think the game in this country is in a far better place than what it is in Spain or in Italy," Neville said last season.
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“If Manchester United or Arsenal win the league, throw open your stadium. Champions League game for Chelsea - why not play it at Stamford Bridge? Get 30,000 or 40,000."
Tickets for the game will cost £7 for adults while children will go free.