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3D Amplified Single-Cell RNA and Protein Imaging Identifies Oncogenic Transcript Subtypes in B-Cell Acute Lymphoblastic Leukemia

ACS Publications
We present a 3D single-cell imaging technique, termed 3D digital rolling circle amplification (4DRCA), capable of the multiplexed and amplified simultaneous...
9 months ago

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Nature
Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrPC) into a...
8 months ago

Targeting the secretory program of 3q-amplified lung cancers

JCI.org
GOLIM4, an integral Golgi membrane protein that is upregulated in 3q-amplified malignancies, interacts with the Ca 2+ /Mn 2+ channel ATP2C1 and the vesicle-...
5 months ago

Change in MYCN-driven cell state opens therapeutic window in high-risk neuroblastoma

St. Jude Children's Research Hospital
A switch between cell states within MYCN-amplified neuroblastoma promotes KDM4, inhibition of which shows promising anticancer potential.
8 months ago

New method enables amplifiable protein identification from trace samples

Phys.org
In a study published in the journal National Science Review, researchers developed an amplifiable protein identification method called "AmproCode."
4 months ago

Signal amplification by cyclic extension enables high-sensitivity single-cell mass cytometry

Nature
Mass cytometry uses metal-isotope-tagged antibodies to label targets of interest, which enables simultaneous measurements of ~50 proteins or protein...
4 months ago

Rapid on-site amplification and visual detection of misfolded proteins via microfluidic quaking-induced conversion (Micro-QuIC)

Nature
We introduce the microfluidic quaking-induced conversion (Micro-QuIC), a novel acoustofluidic platform for the rapid and sensitive detection of protein...
4 months ago

Single-Molecule Fingerprinting Reveals Different Growth Mechanisms in Seed Amplification Assays for Different Polymorphs of α-Synuclein Fibrils

ACS Publications
α-Synuclein (αSyn) aggregates, detected in the biofluids of patients with Parkinson's disease (PD), have the ability to catalyze their own aggregation,...
3 months ago

Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification

Nature
The microsporidian Enterocytozoon hepatopenaei (EHP) is a major threat to shrimp health worldwide. Severe EHP infections in shrimp cause growth retardation...
9 months ago

Amplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid

Nature
We design a self-assembled nanoparticle-mediated amplified fluorogenic immunoassay (SNAFIA) consisting of magnetic and fluorophore-loaded polymeric...
11 months ago