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Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues

Nature
Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity and throughput. Here we report immunostaining...
63 months ago

3D Amplified Single-Cell RNA and Protein Imaging Identifies Oncogenic Transcript Subtypes in B-Cell Acute Lymphoblastic Leukemia

ACS Publications
We present a 3D single-cell imaging technique, termed 3D digital rolling circle amplification (4DRCA), capable of the multiplexed and amplified simultaneous...
9 months ago

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects

Wiley Online Library
Nanoengineered PROteolysis TArgeting Chimeras (Nano-PROTACs) are developed with glutathione (GSH)-responsive polymeric nanoparticles and...
19 months ago

Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin

Frontiers
Novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered by incorporation of an ErbB2-dependant penetrating peptide.
5 months ago

Zeptomole Detection of C-Reactive Protein in Serum by a Nanoparticle Amplified Surface Plasmon Resonance Imaging Aptasensor

Nature
It was possible to measure 7 zeptomole (at 5 fg/mL) of C-reactive protein (CRP) selectively in spiked human serum.
126 months ago

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Nature
Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein...
8 months ago

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

Nature
Here we report a procedure involving cyclic amplification of protein misfolding that allows a rapid conversion of large excess PrP C into a protease-resistant,...
281 months ago

Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop

Nature
Type I interferon (IFN-I) is critical for a host against viral and bacterial infections via induction of hundreds of interferon-stimulated...
105 months ago

Protein misfolding cyclic amplification of infectious prions

Nature
Protein misfolding cyclic amplification (PMCA), described in detail in this protocol, is a simple, fast and efficient methodology to mimic prion...
149 months ago

Multiplexed protein profiling on microarrays by rolling-circle amplification

Nature
A total of 75 cytokines were measured simultaneously on glass arrays with signal amplification by RCA with high specificity, femtomolar sensitivity, 3 log...
272 months ago