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Signal amplification by cyclic extension enables high-sensitivity single-cell mass cytometry
Nature
Mass cytometry uses metal-isotope-tagged antibodies to label targets of interest, which enables simultaneous measurements of ~50 proteins or...
3 months ago
3D Amplified Single-Cell RNA and Protein Imaging Identifies Oncogenic Transcript Subtypes in B-Cell Acute Lymphoblastic Leukemia
ACS Publications
Here, we present a 3D amplified single-cell imaging technique, termed 3D digital RCA (4DRCA), which enables the multiplexed and amplified...
8 months ago
ACE technology enhances single-cell protein detection with advanced signal amplification
News-Medical
"ACE helps to close a crucial gap in cytometric analysis: by enhancing the sensitivity of mass cytometry, it enables a single cell analysis...
3 months ago
Rapid on-site amplification and visual detection of misfolded proteins via microfluidic quaking-induced conversion (Micro-QuIC)
Nature
The integration of Micro-QuIC with nanoparticle-enhanced QuIC methods, such as Nano-QuIC or AuNP assay, suggests promising potential toward...
3 months ago
3D Amplified Single-Cell RNA and Protein Imaging Identifies Oncogenic Transcript Subtypes in B-Cell Acute Lymphoblastic Leukemia
ACS Publications
Here, we present a 3D single-cell imaging technique, termed 3D digital rolling circle amplification (4DRCA), capable of the multiplexed and...
8 months ago
Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects
Wiley Online Library
Advanced Science is a high-impact, interdisciplinary science journal covering materials science, physics, chemistry, medical and life...
18 months ago
Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection
ScienceDirect.com
Sporozoite neutralization by CSP-specific antibodies in the skin can thus be described as a progressive cytotoxic process starting with the...
15 months ago
Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification
Nature
The microsporidian Enterocytozoon hepatopenaei (EHP) is a major threat to shrimp health worldwide. Severe EHP infections in shrimp cause...
8 months ago
Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues
Nature
Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity and throughput. Here we report immunostaining...
62 months ago
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma
Nature
Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive...
22 months ago