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Signal amplification by cyclic extension enables high-sensitivity single-cell mass cytometry

Nature
Mass cytometry uses metal-isotope-tagged antibodies to label targets of interest, which enables simultaneous measurements of ~50 proteins or...
2 months ago

Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin

Frontiers
Novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered by incorporation of an ErbB2-dependant penetrating peptide.
3 months ago

Rapid on-site amplification and visual detection of misfolded proteins via microfluidic quaking-induced conversion (Micro-QuIC)

Nature
We introduce the microfluidic quaking-induced conversion (Micro-QuIC), a novel acoustofluidic platform for the rapid and sensitive detection of protein...
2 months ago

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects

Wiley Online Library
This ARV@PDSA Nano-PROTACs strategy shows superior anti-tumor efficacy with a low dose administration and good biocompatibility in vivo.
17 months ago

Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification

Nature
We injected EhPTP2-specific double-stranded RNA (dsRNA) and found that it significantly diminished EHP copy numbers in infected shrimp.
7 months ago

Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues

Nature
Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity and throughput. Here we report immunostaining...
61 months ago

Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

Nature
Here we show that the RNA-binding protein, Musashi-1 (MSI1) is an essential mediator of G3 MB in both MYC-overexpressing mouse models and patient-derived...
22 months ago

Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures

Nature
Cells respond to external forces by amplifying transiently and locally cytoskeleton displacements, enabling protein deformation and recruitment in...
50 months ago

Zeptomole Detection of C-Reactive Protein in Serum by a Nanoparticle Amplified Surface Plasmon Resonance Imaging Aptasensor

Nature
It was possible to measure 7 zeptomole (at 5 fg/mL) of C-reactive protein (CRP) selectively in spiked human serum.
124 months ago

An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells

Nature
We used a combination of a human artificial chromosome (HAC) vector and initiation region (IR)/matrix attachment region (MAR) gene amplification method to...
58 months ago