This invention provides methods of obtaining vaccines by use of non-stochastic methods of directed evolution (DirectEvolution). These methods include non-stochastic polynucleotide site-satuaration mutagenesis (Gene Site Saturation Mutagenesis) and non-stochastic polynucleotide reassembly (GeneReassembly)....http://www.google.co.uk/patents/US6479258?utm_source=gb-gplus-sharePatent US6479258 - Non-stochastic generation of genetic vaccines
