A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a...http://www.google.co.uk/patents/US6008031?utm_source=gb-gplus-sharePatent US6008031 - Method of analysis and manipulation of DNA utilizing mismatch repair systems