A composite living skin equivalent is described comprising an epidermal layer of cultured keratinocyte cells, a layer of non-porous collagen, and a dermal layer of cultured fibroblast cells in a porous cross-linked collagen sponge matrix. Preferably the non-porous collagen is Type 1, Type 3 or mixtures...http://www.google.co.uk/patents/USRE35399?utm_source=gb-gplus-sharePatent USRE35399 - Composite living skin equivalents