Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources...http://www.google.co.uk/patents/US6087487?utm_source=gb-gplus-sharePatent US6087487 - Nematode-extracted serine protease inhibitors and anticoagulant proteins