Method for the site specific genomic modification of yeasts of the genus Pichia and novel DNA sequences useful therefore are provided. Pichia is transformed with a serially arranged linear DNA fragment comprising first and second insertable DNA fragments, which flank a marker gene. The insertable DNA...http://www.google.co.uk/patents/US5166329?utm_source=gb-gplus-sharePatent US5166329 - DNA encoding the alcohol oxidase 2 gene of yeast of the genus Pichia