WO2012118819A3 - Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same - Google Patents

Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same Download PDF

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Publication number
WO2012118819A3
WO2012118819A3 PCT/US2012/026960 US2012026960W WO2012118819A3 WO 2012118819 A3 WO2012118819 A3 WO 2012118819A3 US 2012026960 W US2012026960 W US 2012026960W WO 2012118819 A3 WO2012118819 A3 WO 2012118819A3
Authority
WO
WIPO (PCT)
Prior art keywords
silica particles
nitrosothiol
methods
functionalized
thiol
Prior art date
Application number
PCT/US2012/026960
Other languages
French (fr)
Other versions
WO2012118819A2 (en
Inventor
Mark Schoenfisch
Daniel Riccio
Julia NUGENT
Nathan Stasko
Original Assignee
Novan, Inc.
The University Of North Carolina At Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novan, Inc., The University Of North Carolina At Chapel Hill filed Critical Novan, Inc.
Priority to ES12752627T priority Critical patent/ES2695173T3/en
Priority to EP12752627.5A priority patent/EP2681286B1/en
Publication of WO2012118819A2 publication Critical patent/WO2012118819A2/en
Priority to US13/975,930 priority patent/US9713652B2/en
Publication of WO2012118819A3 publication Critical patent/WO2012118819A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • C07F7/0872—Preparation and treatment thereof
    • C07F7/0874—Reactions involving a bond of the Si-O-Si linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/26—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
    • C08G77/28—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/28—Nitrogen-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/02—Elements
    • C08K2003/023—Silicon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Abstract

Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.
PCT/US2012/026960 2011-02-28 2012-02-28 Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same WO2012118819A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES12752627T ES2695173T3 (en) 2011-02-28 2012-02-28 Silica particles modified with S-nitrosothiol that release nitric oxide and methods of manufacturing them
EP12752627.5A EP2681286B1 (en) 2011-02-28 2012-02-28 Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same
US13/975,930 US9713652B2 (en) 2011-02-28 2013-08-26 Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161447368P 2011-02-28 2011-02-28
US61/447,368 2011-02-28
US201161565694P 2011-12-01 2011-12-01
US61/565,694 2011-12-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/975,930 Continuation US9713652B2 (en) 2011-02-28 2013-08-26 Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same

Publications (2)

Publication Number Publication Date
WO2012118819A2 WO2012118819A2 (en) 2012-09-07
WO2012118819A3 true WO2012118819A3 (en) 2014-04-17

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2012/026960 WO2012118819A2 (en) 2011-02-28 2012-02-28 Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same
PCT/US2012/026972 WO2012118829A2 (en) 2011-02-28 2012-02-28 Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2012/026972 WO2012118829A2 (en) 2011-02-28 2012-02-28 Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same

Country Status (4)

Country Link
US (2) US8981139B2 (en)
EP (1) EP2681286B1 (en)
ES (1) ES2695173T3 (en)
WO (2) WO2012118819A2 (en)

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