WO2011154482A3 - Assembly for a drug delivery device and drug delivery device - Google Patents

Assembly for a drug delivery device and drug delivery device Download PDF

Info

Publication number
WO2011154482A3
WO2011154482A3 PCT/EP2011/059566 EP2011059566W WO2011154482A3 WO 2011154482 A3 WO2011154482 A3 WO 2011154482A3 EP 2011059566 W EP2011059566 W EP 2011059566W WO 2011154482 A3 WO2011154482 A3 WO 2011154482A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery device
drug delivery
rotation member
assembly
rotation
Prior art date
Application number
PCT/EP2011/059566
Other languages
French (fr)
Other versions
WO2011154482A2 (en
Inventor
Steffen Raab
Mark Philip Horlock
Stephen David Butler
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Priority to EP11724218.0A priority Critical patent/EP2579920B1/en
Priority to US13/701,969 priority patent/US9623185B2/en
Priority to CA2801635A priority patent/CA2801635A1/en
Priority to JP2013513688A priority patent/JP2013528086A/en
Priority to DK11724218T priority patent/DK2579920T3/en
Publication of WO2011154482A2 publication Critical patent/WO2011154482A2/en
Publication of WO2011154482A3 publication Critical patent/WO2011154482A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An assembly for a drug delivery device (1) is provided, comprising a housing (2), a rotation member (17) adapted and arranged to be rotated in a first and in a second rotational direction with respect to the housing (2) in an operational mode of the assembly, a drive member (16) which is configured to mechanically cooperate with the rotation member (17) such that the drive member (16) follows rotation of the rotation member (17) when the rotation member (17) is rotated in the second rotational direction and such that the rotation member (17) rotates with respect to the drive member (16) when the rotation member (17) is rotated in the first rotational direction, and a piston rod (12). The assembly further comprises at least one biasing member (27) which is adapted and arranged to provide a force tending to bring the rotation member (17) and the drive member (16) out of mechanical cooperation in the operational mode. The assembly is switchable from the operational mode into a reset mode. For switching from the operational mode into the reset mode, the biasing member (27) is configured to drive a relative axial movement between the drive member (16) and the rotation member (17) such that the rotation member (17) and the drive member (16) are brought out of mechanical cooperation. Furthermore, a drug delivery device (1) is provided.
PCT/EP2011/059566 2010-06-11 2011-06-09 Assembly for a drug delivery device and drug delivery device WO2011154482A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP11724218.0A EP2579920B1 (en) 2010-06-11 2011-06-09 Assembly for a drug delivery device and drug delivery device
US13/701,969 US9623185B2 (en) 2010-06-11 2011-06-09 Assembly for a drug delivery device and drug delivery device
CA2801635A CA2801635A1 (en) 2010-06-11 2011-06-09 Assembly for a drug delivery device and drug delivery device
JP2013513688A JP2013528086A (en) 2010-06-11 2011-06-09 Assembly for drug delivery device and drug delivery device
DK11724218T DK2579920T3 (en) 2010-06-11 2011-06-09 DEVICE FOR A PHARMACEUTICAL ADMINISTRATION DEVICE AND PHARMACEUTICAL ADMINISTRATION DEVICE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10165639 2010-06-11
EP10165639.5 2010-06-11

Publications (2)

Publication Number Publication Date
WO2011154482A2 WO2011154482A2 (en) 2011-12-15
WO2011154482A3 true WO2011154482A3 (en) 2012-02-02

Family

ID=43039232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/059566 WO2011154482A2 (en) 2010-06-11 2011-06-09 Assembly for a drug delivery device and drug delivery device

Country Status (8)

Country Link
US (1) US9623185B2 (en)
EP (1) EP2579920B1 (en)
JP (1) JP2013528086A (en)
AR (1) AR081598A1 (en)
CA (1) CA2801635A1 (en)
DK (1) DK2579920T3 (en)
TW (1) TW201210648A (en)
WO (1) WO2011154482A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105209094A (en) * 2013-05-21 2015-12-30 诺和诺德股份有限公司 Frontloaded drug delivery device with actuated cartridge holder and piston rod coupling
CN105307712A (en) * 2013-05-21 2016-02-03 诺和诺德股份有限公司 Frontloaded drug delivery device with dynamic axial stop feature

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2854907B1 (en) 2012-05-30 2019-01-16 Sanofi-Aventis Deutschland GmbH Drive mechanism for a drug delivery device and drug delivery device
US10046118B2 (en) 2012-05-30 2018-08-14 Sanofi-Aventis Deutschland Gmbh Bearing for a piston rod body for a drug delivery device, a piston rod arrangement and a piston rod body
EP2999504A1 (en) * 2013-05-21 2016-03-30 Novo Nordisk A/S Drug delivery device with piston rod coupling
JP6815198B2 (en) * 2013-11-22 2021-01-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drug delivery device with unidirectional coupling
EP2881132B1 (en) * 2013-12-05 2017-10-18 TecPharma Licensing AG Injection device with an improved metering member and a pre-tensioned ejection spring
US10653840B2 (en) * 2014-10-09 2020-05-19 Sanofi Housing and drug delivery device herewith
US10518036B2 (en) 2014-12-12 2019-12-31 SHL Medical, AG Dose setting mechanism and medicament delivery device comprising the dose setting mechanism
US10596328B2 (en) 2014-12-22 2020-03-24 Novo Nordisk A/S Spring-driven drug delivery device
KR102592490B1 (en) * 2017-03-07 2023-10-23 사노피-아벤티스 도이칠란트 게엠베하 Cap assembly for a drug delivery device, kit for assembling a cap, method for assembling a cap and drug delivery device comprising a cap assembly
TWI668025B (en) * 2017-04-21 2019-08-11 瑞士商瑞健醫療股份有限公司 Administration assembly for a medicament delivery device
EP3598990A1 (en) 2018-07-23 2020-01-29 Sanofi Drug delivery device and assembly method for a drug delivery device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007922A1 (en) * 1991-10-18 1993-04-29 Novo Nordisk A/S Large dose pen
US5827232A (en) * 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US20020111587A1 (en) * 2001-02-15 2002-08-15 Edgar Hommann Injection device for injecting fluid
WO2006058061A1 (en) * 2004-11-24 2006-06-01 Becton Dickinson And Company Automatic reconstitution injector device
US20060153693A1 (en) * 2004-12-31 2006-07-13 Patrick Fiechter Administering apparatus comprising a service life timer

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* Cited by examiner, † Cited by third party
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JPH08730B2 (en) 1987-10-27 1996-01-10 秩父小野田株式会社 Titanium carbonitride sintered body and method for producing the same
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5833634A (en) 1995-11-09 1998-11-10 Uromed Corporation Tissue examination
EP2258425B1 (en) 2001-05-16 2013-01-30 Eli Lilly and Company Medication injector apparatus
US6932794B2 (en) * 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
DE102007026083A1 (en) 2007-05-25 2008-11-27 Haselmeier S.A.R.L. injection device
US8187233B2 (en) 2008-05-02 2012-05-29 Sanofi-Aventis Deutschland Gmbh Medication delivery device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007922A1 (en) * 1991-10-18 1993-04-29 Novo Nordisk A/S Large dose pen
US5827232A (en) * 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US20020111587A1 (en) * 2001-02-15 2002-08-15 Edgar Hommann Injection device for injecting fluid
WO2006058061A1 (en) * 2004-11-24 2006-06-01 Becton Dickinson And Company Automatic reconstitution injector device
US20060153693A1 (en) * 2004-12-31 2006-07-13 Patrick Fiechter Administering apparatus comprising a service life timer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105209094A (en) * 2013-05-21 2015-12-30 诺和诺德股份有限公司 Frontloaded drug delivery device with actuated cartridge holder and piston rod coupling
CN105307712A (en) * 2013-05-21 2016-02-03 诺和诺德股份有限公司 Frontloaded drug delivery device with dynamic axial stop feature

Also Published As

Publication number Publication date
AR081598A1 (en) 2012-10-03
TW201210648A (en) 2012-03-16
JP2013528086A (en) 2013-07-08
EP2579920A2 (en) 2013-04-17
WO2011154482A2 (en) 2011-12-15
US20130211342A1 (en) 2013-08-15
EP2579920B1 (en) 2019-07-31
DK2579920T3 (en) 2019-11-04
CA2801635A1 (en) 2011-12-15
US9623185B2 (en) 2017-04-18

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