WO2011132939A3 - Rtk-bpb specifically binding to rtk - Google Patents
Rtk-bpb specifically binding to rtk Download PDFInfo
- Publication number
- WO2011132939A3 WO2011132939A3 PCT/KR2011/002839 KR2011002839W WO2011132939A3 WO 2011132939 A3 WO2011132939 A3 WO 2011132939A3 KR 2011002839 W KR2011002839 W KR 2011002839W WO 2011132939 A3 WO2011132939 A3 WO 2011132939A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rtk
- present
- peptide binder
- bipodal peptide
- specifically binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention relates to an RTK-bipodal peptide binder specifically binding to RTK, comprising: (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which interstrand non-covalent bonds are formed; and (b) an RTK-target binding region I and an RTK-target binding region II which bond to both terminals of the structure stabilizing region and which comprise n and m amino acids randomly selected, respectively. The RTK-bipodal peptide binder of the present invention exhibits a very low KD value (dissociation constant) (for example, nM level) relative to RTK and therefore exhibits a very high affinity toward an RTK target. The RTK-bipodal peptide binder of the present invention may have a use as a medicine, may be used for in vivo molecular imaging and drug delivery targeting, and may be very useful as an escort molecule.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020127023553A KR20130103302A (en) | 2010-04-20 | 2011-04-20 | Cytokine-bpb specifically binding to cytokine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20100036607 | 2010-04-20 | ||
KR10-2010-0036607 | 2010-04-20 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2011132939A2 WO2011132939A2 (en) | 2011-10-27 |
WO2011132939A3 true WO2011132939A3 (en) | 2012-04-05 |
WO2011132939A8 WO2011132939A8 (en) | 2012-08-09 |
Family
ID=44834645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2011/002839 WO2011132939A2 (en) | 2010-04-20 | 2011-04-20 | Rtk-bpb specifically binding to rtk |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR20130103302A (en) |
WO (1) | WO2011132939A2 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
JP2001002592A (en) * | 1999-06-18 | 2001-01-09 | Dai Ichi Seiyaku Co Ltd | Composition for gene-transducing |
US20040152647A1 (en) * | 2003-01-31 | 2004-08-05 | Max-Delbruck-Cenrum Fur Molekulare Medizin | Agent for gene transfer |
US6914123B2 (en) * | 2001-04-17 | 2005-07-05 | Genentech, Inc. | Hairpin peptides with a novel structural motif and methods relating thereto |
WO2010047515A2 (en) * | 2008-10-20 | 2010-04-29 | 광주과학기술원 | Bipodal peptide binder |
-
2011
- 2011-04-20 WO PCT/KR2011/002839 patent/WO2011132939A2/en active Application Filing
- 2011-04-20 KR KR1020127023553A patent/KR20130103302A/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
JP2001002592A (en) * | 1999-06-18 | 2001-01-09 | Dai Ichi Seiyaku Co Ltd | Composition for gene-transducing |
US6914123B2 (en) * | 2001-04-17 | 2005-07-05 | Genentech, Inc. | Hairpin peptides with a novel structural motif and methods relating thereto |
US20040152647A1 (en) * | 2003-01-31 | 2004-08-05 | Max-Delbruck-Cenrum Fur Molekulare Medizin | Agent for gene transfer |
WO2010047515A2 (en) * | 2008-10-20 | 2010-04-29 | 광주과학기술원 | Bipodal peptide binder |
Non-Patent Citations (2)
Title |
---|
TIM CLACKSON ET AL.: "Making antibody fragments using phage display libraries", NATURE, vol. 352, 15 August 1991 (1991-08-15), pages 624 - 628 * |
VAISHALI BAGALKOT ET AL.: "An Aptamer-Doxorubicin Physical Conjugate as a Novel Targeted Drug-Delivery Platform", ANGEW. CHEM. INT. ED., vol. 45, 2006, pages 8149 - 8152 * |
Also Published As
Publication number | Publication date |
---|---|
WO2011132939A2 (en) | 2011-10-27 |
KR20130103302A (en) | 2013-09-23 |
WO2011132939A8 (en) | 2012-08-09 |
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