WO2011035001A8 - Novel heparin entities and methods of use - Google Patents

Novel heparin entities and methods of use Download PDF

Info

Publication number
WO2011035001A8
WO2011035001A8 PCT/US2010/049078 US2010049078W WO2011035001A8 WO 2011035001 A8 WO2011035001 A8 WO 2011035001A8 US 2010049078 W US2010049078 W US 2010049078W WO 2011035001 A8 WO2011035001 A8 WO 2011035001A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
novel heparin
heparin
heparin entities
bound
Prior art date
Application number
PCT/US2010/049078
Other languages
French (fr)
Other versions
WO2011035001A2 (en
WO2011035001A3 (en
Inventor
Roy Biran
Charles D. Claude
Robert L. Cleek
Paul D. Drumheller
Mei Li
Nora Mardirosian
Original Assignee
Gore Enterprise Holdings, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gore Enterprise Holdings, Inc. filed Critical Gore Enterprise Holdings, Inc.
Priority to RU2012115097/15A priority Critical patent/RU2576803C2/en
Priority to BR112012006144A priority patent/BR112012006144A2/en
Priority to CA2774494A priority patent/CA2774494A1/en
Priority to CN201080051584.5A priority patent/CN102695530B/en
Priority to AU2010295601A priority patent/AU2010295601B2/en
Priority to EP10755304.2A priority patent/EP2477668B1/en
Priority to ES10755304.2T priority patent/ES2668220T3/en
Priority to JP2012529895A priority patent/JP5814242B2/en
Publication of WO2011035001A2 publication Critical patent/WO2011035001A2/en
Publication of WO2011035001A3 publication Critical patent/WO2011035001A3/en
Publication of WO2011035001A8 publication Critical patent/WO2011035001A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A61L33/128—Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Abstract

The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.
PCT/US2010/049078 2009-09-17 2010-09-16 Novel heparin entities and methods of use WO2011035001A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
RU2012115097/15A RU2576803C2 (en) 2009-09-17 2010-09-16 New heparin particles and methods for using them
BR112012006144A BR112012006144A2 (en) 2009-09-17 2010-09-16 new heparin individualities and methods of use.
CA2774494A CA2774494A1 (en) 2009-09-17 2010-09-16 Novel heparin entities and methods of use
CN201080051584.5A CN102695530B (en) 2009-09-17 2010-09-16 Novel heparin entity and its application method
AU2010295601A AU2010295601B2 (en) 2009-09-17 2010-09-16 Novel heparin entities and methods of use
EP10755304.2A EP2477668B1 (en) 2009-09-17 2010-09-16 Novel heparin entities and methods of use
ES10755304.2T ES2668220T3 (en) 2009-09-17 2010-09-16 New heparin entities and methods of use
JP2012529895A JP5814242B2 (en) 2009-09-17 2010-09-16 Novel heparin and its utilization

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12/561,927 US8591932B2 (en) 2009-09-17 2009-09-17 Heparin entities and methods of use
US12/561,927 2009-09-17
US12/579,308 US20110065085A1 (en) 2009-09-17 2009-10-14 Novel heparin entities and methods of use
US12/579,308 2009-10-14

Publications (3)

Publication Number Publication Date
WO2011035001A2 WO2011035001A2 (en) 2011-03-24
WO2011035001A3 WO2011035001A3 (en) 2011-08-18
WO2011035001A8 true WO2011035001A8 (en) 2012-04-19

Family

ID=43730811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/049078 WO2011035001A2 (en) 2009-09-17 2010-09-16 Novel heparin entities and methods of use

Country Status (10)

Country Link
US (3) US8591932B2 (en)
EP (1) EP2477668B1 (en)
JP (3) JP5814242B2 (en)
CN (1) CN102695530B (en)
AU (1) AU2010295601B2 (en)
BR (1) BR112012006144A2 (en)
CA (2) CA2774494A1 (en)
ES (1) ES2668220T3 (en)
RU (1) RU2576803C2 (en)
WO (1) WO2011035001A2 (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8157951B2 (en) * 2005-10-11 2012-04-17 Applied Materials, Inc. Capacitively coupled plasma reactor having very agile wafer temperature control
US20130110137A1 (en) * 2007-04-02 2013-05-02 Ension, Inc. Surface Treated Polymeric Synthetic Hernia Mesh Prosthesis, Surface Treated Sutures and Staples and Methods of Manufacturing the Same
US9744033B2 (en) 2011-04-01 2017-08-29 W.L. Gore & Associates, Inc. Elastomeric leaflet for prosthetic heart valves
US9554806B2 (en) 2011-09-16 2017-01-31 W. L. Gore & Associates, Inc. Occlusive devices
AR087037A1 (en) * 2012-07-02 2014-02-12 Consejo Nac Invest Cient Tec AMILOID FIBERS OF LISOZIMA, SOLID SUPPORT, BIOCATALIZER AND PROCEDURES
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
CN102796723A (en) * 2012-09-11 2012-11-28 深圳市海普瑞药业股份有限公司 Method for immobilizing heparanase I
US10092653B2 (en) 2012-09-13 2018-10-09 W. L. Gore & Associates, Inc. Polytetrafluoroethylene co-polymer emulsions
CN102888390B (en) * 2012-10-30 2014-09-03 深圳市海普瑞药业股份有限公司 Immobilization method of heparinase III
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US10966820B2 (en) 2012-12-19 2021-04-06 W. L. Gore & Associates, Inc. Geometric control of bending character in prosthetic heart valve leaflets
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9447304B2 (en) 2013-03-14 2016-09-20 W. L. Gore & Associates, Inc. Coating for a surface
JP6336563B2 (en) * 2013-03-15 2018-06-06 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Immobilization of active agent on substrate
US9655917B2 (en) * 2013-06-07 2017-05-23 Baxter International Inc. Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups
US11911258B2 (en) 2013-06-26 2024-02-27 W. L. Gore & Associates, Inc. Space filling devices
US9829483B2 (en) * 2013-09-26 2017-11-28 The General Hospital Corporation Methods of isolating extracellular vesicles
US9504565B2 (en) 2013-12-06 2016-11-29 W. L. Gore & Associates, Inc. Asymmetric opening and closing prosthetic valve leaflet
JP6520706B2 (en) * 2014-02-12 2019-05-29 東レ株式会社 Artificial blood vessel
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
JP6445683B2 (en) 2014-08-18 2018-12-26 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ Frame with integral suture cuff for a prosthetic valve
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
JP2018515246A (en) 2015-05-14 2018-06-14 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ Devices and methods for atrial appendage occlusion
EP3095509A1 (en) 2015-05-18 2016-11-23 Defymed Membranes functionalized with heparin for bioartificial organs
US10525376B2 (en) 2015-07-20 2020-01-07 W. L. Gore & Associates, Inc. Affinity chromatography devices
US10526367B2 (en) 2015-07-20 2020-01-07 W. L. Gore & Associates, Inc. Affinity chromatography devices
WO2017132642A1 (en) * 2016-01-29 2017-08-03 The Regents Of The University Of California A wearable sensor, and method, to monitor anti-coagulation therapy
JP6788028B2 (en) 2016-04-08 2020-11-18 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ Affinity chromatograph device
US11173235B2 (en) 2016-07-15 2021-11-16 Cook Regentec Llc Nitrite eluting devices and methods of use thereof
RU2650667C1 (en) * 2016-12-02 2018-04-16 Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) Mutant recombinant heparinase i with increased specific activity from pedobacter heparinus, dna fragment that codes the said heparinase
CA3071133C (en) 2017-09-12 2023-02-28 W.L. Gore & Associates, Inc. Leaflet frame attachment for prosthetic valves
WO2019067220A1 (en) 2017-09-27 2019-04-04 W. L. Gore & Associates, Inc. Prosthetic valves with mechanically coupled leaflets
CA3072814C (en) 2017-09-27 2023-01-03 W.L. Gore & Associates, Inc. Prosthetic valve with expandable frame and associated systems and methods
CA3078699C (en) 2017-10-13 2023-10-10 W.L. Gore & Associates, Inc. Telescoping prosthetic valve and delivery system
US11173023B2 (en) 2017-10-16 2021-11-16 W. L. Gore & Associates, Inc. Medical devices and anchors therefor
WO2019089135A1 (en) 2017-10-31 2019-05-09 W. L. Gore & Associates, Inc. Transcatheter deployment systems and associated methods
US11154397B2 (en) 2017-10-31 2021-10-26 W. L. Gore & Associates, Inc. Jacket for surgical heart valve
AU2018362081B2 (en) 2017-10-31 2021-05-06 Edwards Lifesciences Corporation Prosthetic heart valve
WO2019089136A1 (en) 2017-10-31 2019-05-09 W. L. Gore & Associates, Inc. Medical valve and leaflet promoting tissue ingrowth
EP3781222A4 (en) * 2018-04-20 2022-01-26 Ension, Inc. Engineered heparin bioactive matrix for clinical application of blood contacting surface and method of manufacturing the same
US20210338905A1 (en) 2018-09-06 2021-11-04 Biomodics Aps A medical tubular device
CN113260441A (en) 2018-11-05 2021-08-13 W.L.戈尔及同仁股份有限公司 Spiral wound protein separation device
USD926322S1 (en) 2018-11-07 2021-07-27 W. L. Gore & Associates, Inc. Heart valve cover
CN109709292A (en) * 2018-12-29 2019-05-03 贵州金玖生物技术有限公司 A kind of heparin detection kit and its application
US11497601B2 (en) 2019-03-01 2022-11-15 W. L. Gore & Associates, Inc. Telescoping prosthetic valve with retention element
CN110917410B (en) * 2019-11-14 2020-11-24 浙江大学 Cardiovascular stent coating based on double-layer heterogeneous structure and preparation method thereof
CN111826418A (en) * 2020-08-28 2020-10-27 保定天岳生物工程有限公司 Antithrombin III determination kit
CN116033949A (en) 2020-09-11 2023-04-28 W.L.戈尔及同仁股份有限公司 Affinity chromatography device comprising fibrillated heat treated polymer membrane and collector comprising the same
CA3213305A1 (en) 2021-04-19 2022-10-27 Mark D. Edmundson Electrochemical analyte biosensors, associated compositions of matter, and methods for making and using same
CN113786518A (en) * 2021-09-15 2021-12-14 海思盖德(苏州)生物医学科技有限公司 Preparation method of composite coating for surface modification of medical material
EP4218981A1 (en) 2022-02-01 2023-08-02 W. L. Gore & Associates, Inc. Affinity chromatography devices containing a fibrillated polymer membrane for the separation of mrna and viral vectors from an aqueous mixture
EP4218980A1 (en) 2022-02-01 2023-08-02 W.L. Gore & Associates Inc. Affinity chromatography devices containing a heat treated fibrillated polymer membrane for the separation of mrna and viral vectors from an aqueous mixture
CN115998963B (en) * 2023-03-22 2023-07-21 上海发微医用材料有限公司 Anticoagulation coating and preparation method and application thereof

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392582B (en) 1970-05-21 1977-04-04 Gore & Ass PROCEDURE FOR THE PREPARATION OF A POROST MATERIAL, BY EXPANDING AND STRETCHING A TETRAFLUORETENE POLYMER PREPARED IN AN PASTE-FORMING EXTENSION PROCEDURE
US4329383A (en) 1979-07-24 1982-05-11 Nippon Zeon Co., Ltd. Non-thrombogenic material comprising substrate which has been reacted with heparin
US4415490A (en) 1979-07-24 1983-11-15 Nippon Zeon Co., Ltd. Non-thrombogenic material
US4326532A (en) 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
US4526714A (en) 1982-12-13 1985-07-02 Cordis Europa N.V. Conjugates of anticoagulant and protein
US4678671A (en) 1981-12-15 1987-07-07 Cordis Europa N.V. Conjugates of anticoagulant and protein
SE456347B (en) 1982-02-09 1988-09-26 Ird Biomaterial Ab SURFACE MODIFIED SOLID SUBSTRATE AND PROCEDURES FOR PRODUCING THEREOF
SE8200751L (en) 1982-02-09 1983-08-10 Olle Larm PROCEDURE FOR COVALENT COUPLING FOR MANUFACTURE OF CONJUGATE AND REQUIRED PRODUCTS
US4600652A (en) 1985-04-01 1986-07-15 Warner-Lambert Company Permanently bonded antithrombogenic polyurethane surface
IT1213023B (en) 1986-01-16 1989-12-07 Rolando Barbucci MATERIAL ABLE TO ADSORBE STABLY HIGH QUANTITIES OF HEPARIN, AND ITS PREPARATION PROCEDURE.
SE452551B (en) 1986-05-27 1987-12-07 Camurus Ab ARTICLE COVERED WITH HEPARIN BASED MATERIAL AND PROCEDURE FOR ITS MANUFACTURING
US4745180A (en) 1986-06-27 1988-05-17 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using heparin fragments
US5527524A (en) 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5308617A (en) 1988-08-10 1994-05-03 Halzyme Ltd. Protein heparin conjugates
US5130143A (en) 1988-11-04 1992-07-14 The Research Foundation Of State University Of New York Use of a low affinity-heparin fraction in conjunction with t-pa for thrombolytic therapy
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5032666A (en) 1989-06-19 1991-07-16 Becton, Dickinson And Company Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface
US5213898A (en) 1989-10-12 1993-05-25 Norsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5049403A (en) 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
WO1993005825A1 (en) 1991-09-20 1993-04-01 Baxter International Inc. Processes for reducing the thrombogenicity of biomaterials
SE470006B (en) 1991-09-26 1993-10-25 Corline Systems Ab New conjugate, its preparation and use, and substrates prepared with the conjugate
US5532311A (en) 1995-02-01 1996-07-02 Minnesota Mining And Manufacturing Company Process for modifying surfaces
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US5583213A (en) 1995-05-12 1996-12-10 Minnesota Mining And Manufacturing Company Process to activate sulfated polysaccharides
US5767108A (en) 1995-08-22 1998-06-16 Medtronic, Inc. Method for making improved heparinized biomaterials
US5679659A (en) 1995-08-22 1997-10-21 Medtronic, Inc. Method for making heparinized biomaterials
US7045585B2 (en) 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
NZ325248A (en) 1995-12-23 1999-09-29 Pfizer Res & Dev Quinoline and quinazoline compounds useful in therapy
US5922690A (en) 1996-04-25 1999-07-13 Van Gorp; Cornelius L. Dermatan disulfate, an inhibitor of thrombin generation and activation
GB9608882D0 (en) 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers
US5876433A (en) 1996-05-29 1999-03-02 Ethicon, Inc. Stent and method of varying amounts of heparin coated thereon to control treatment
US5916585A (en) 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5914182A (en) 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US5728751A (en) 1996-11-25 1998-03-17 Meadox Medicals, Inc. Bonding bio-active materials to substrate surfaces
JPH114883A (en) 1997-06-18 1999-01-12 Toray Ind Inc Anti-thrombogenic medical material
CA2305726A1 (en) 1997-10-07 1999-04-15 Regents Of The University Of California Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine
FI974321A0 (en) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multiple heparinglycosaminoglycans and proteoglycans are used
AU4679499A (en) 1998-06-10 1999-12-30 Advanced Bypass Technologies, Inc. Thermal securing anastomosis systems
GB9814420D0 (en) 1998-07-03 1998-09-02 Cancer Res Campaign Tech Sequence analysis of saccharide material
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
NO984143L (en) 1998-09-09 2000-03-10 Norsk Hydro As New process for producing surface modifying substances
WO2001066164A1 (en) 1999-04-22 2001-09-13 Eidgenossisch Technische Hochschule Zurich Modified protein matrices
US6936066B2 (en) 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US7736687B2 (en) 2006-01-31 2010-06-15 Advance Bio Prosthetic Surfaces, Ltd. Methods of making medical devices
SE515295C2 (en) * 1999-11-23 2001-07-09 Medicarb Ab Process for the preparation of conjugates of a biologically active polysaccharide and a solid substrate, and such conjugates
GB9928956D0 (en) 1999-12-07 2000-02-02 Malik Navid Internally supported biomimetic coating systems
US6518244B2 (en) 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
US7875283B2 (en) 2000-04-13 2011-01-25 Advanced Cardiovascular Systems, Inc. Biodegradable polymers for use with implantable medical devices
WO2001082992A1 (en) 2000-04-28 2001-11-08 Emory University Decellularized vascular prostheses
EP1280571B1 (en) 2000-05-12 2005-10-26 Cordis Corporation Delivery devices for treatment of vascular disease
US20050059068A1 (en) 2001-05-23 2005-03-17 Stratagene California Compositions and methods using dendrimer-treated microassays
US6787179B2 (en) 2001-06-29 2004-09-07 Ethicon, Inc. Sterilization of bioactive coatings
TWI255224B (en) 2002-01-09 2006-05-21 Novartis Ag Polymeric articles having a lubricious coating and method for making the same
US20030135195A1 (en) 2002-01-16 2003-07-17 Oscar Jimenez Highly lubricious hydrophilic coating utilizing dendrimers
EP1501566B1 (en) * 2002-05-09 2008-08-13 Hemoteq AG Medical products comprising a haemocompatible coating, production and use thereof
JP2005044408A (en) * 2003-07-24 2005-02-17 Pioneer Electronic Corp Optical integrated device and optical pickup device
AU2004266642A1 (en) 2003-08-12 2005-03-03 University Of Utah Research Foundation Heparin binding proteins: sensors for heparin detection
CN1255189C (en) * 2003-10-20 2006-05-10 北京理工大学 Prepn of anticoagulant insoluble silk protein material
CN1256991C (en) * 2003-12-27 2006-05-24 重庆大学 Process for preparing anti-coagulant composite material of polyether urethane heparinized high molecular liquid crystal
US20050244459A1 (en) 2004-04-06 2005-11-03 Dewitt David M Coating compositions for bioactive agents
GB0422877D0 (en) 2004-10-14 2004-11-17 Univ Glasgow Bioactive polymers
JP5178506B2 (en) 2005-03-14 2013-04-10 バイオベンション ホールディングス リミテッド Methods related to drug delivery compositions
US7767420B2 (en) 2005-11-03 2010-08-03 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
US20070212388A1 (en) 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Compositions comprising porous articles and uses in implantable medical devices
US9114194B2 (en) 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
JP2009545333A (en) 2006-05-12 2009-12-24 ゴア エンタープライズ ホールディングス，インコーポレイティド Immobilized bioactive substance having great biological activity after physical manipulation or sterilization
US8986713B2 (en) 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US20080279909A1 (en) 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
WO2008063157A2 (en) 2006-10-25 2008-05-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services A nanoparticle-based anticoagulant
DE102008021894A1 (en) 2008-05-02 2009-11-05 Biotronik Vi Patent Ag Implant comprising a surface with reduced thrombogenicity
GB0816783D0 (en) 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities

Also Published As

Publication number Publication date
JP2017192801A (en) 2017-10-26
JP6538767B2 (en) 2019-07-03
CA2838352A1 (en) 2011-03-24
US8591932B2 (en) 2013-11-26
JP2013505070A (en) 2013-02-14
WO2011035001A2 (en) 2011-03-24
RU2576803C2 (en) 2016-03-10
JP6290840B2 (en) 2018-03-07
JP2016005773A (en) 2016-01-14
US20110064781A1 (en) 2011-03-17
AU2010295601A1 (en) 2012-05-10
CA2774494A1 (en) 2011-03-24
EP2477668B1 (en) 2018-02-07
CA2838352C (en) 2018-04-24
CN102695530A (en) 2012-09-26
CN102695530B (en) 2018-11-30
BR112012006144A2 (en) 2016-06-28
JP5814242B2 (en) 2015-11-17
WO2011035001A3 (en) 2011-08-18
US20110065085A1 (en) 2011-03-17
EP2477668A2 (en) 2012-07-25
US20140128544A1 (en) 2014-05-08
RU2012115097A (en) 2013-10-27
AU2010295601B2 (en) 2014-02-13
ES2668220T3 (en) 2018-05-17

Similar Documents

Publication Publication Date Title
WO2011035001A3 (en) Novel heparin entities and methods of use
WO2009121948A3 (en) Single domain antibodies capable of modulating bace activity
SI1935331T1 (en) Process for the preparation of modified electrodes, electrodes prepared with said process, and enzymatic biosensors comprising said electrodes
WO2007133699A3 (en) Immobilized biologically active entities having a high degree of biological activity following mecanical manipulation or sterilization
WO2008033432A3 (en) Immune modulation by chemically modified ribonucleosides and oligoribonucleotides
BRPI1006215A2 (en) "multispecific antibodies, nucleic acid, host cell, antibody production method, immunoconjugate, pharmaceutical formulation, treatment method, method of inhibiting a biological activity and use of the antibody"
WO2008064265A3 (en) Compounds modulating c-fms and/or c-kit activity and uses therefor
EP2354224A4 (en) Novel protein having fructosyl valyl histidine oxidase activity and modified product thereof, and use of the protein or the modified product
ATE522216T1 (en) USE OF 2-6-(3-AMINE-PIPERIDINE-1-YL)-3-METHYL-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDINE-1-YLMETHYL-4-FLUORO-BENZONITRILE FOR THE TREATMENT OF DIABETES, CANCER, AUTOIMMUNE DISEASES AND HIV INFECTIONS
WO2007025547A3 (en) Layered product with adhesive dressing for non-touch application
EP2099605A4 (en) Composition and articles containing cross-liinked polymer matrix and immobilized active liquid, and methods of making same
WO2009132656A3 (en) Crystal structure of human sortilin and uses thereof for identifying ligands to sortilin
WO2008045021A3 (en) Blood compatible nanomaterials and methods of making and using the same
WO2008029096A8 (en) P53 activating benzoyl urea and benzoyl thiourea compounds
WO2007011639A3 (en) Catalytic immunoglobulins
ATE552336T1 (en) PRODUCTION OF BIOLOGICALLY ACTIVE PROTEINS
WO2006101387A3 (en) Method for interfering with blood coagulation by modulating cross-beta structures fibril formation
WO2012122404A3 (en) Micellar polysiloxane enzyme immobilization materials
WO2009064372A3 (en) Immobilized biologically active entities having a high degree of biological activity
WO2007106915A3 (en) Antibodies to egfl7 and methods for their use
WO2010072740A3 (en) TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF
HUP0600668A2 (en) Active carrier, process for producing thereof and the use of thereof
ZA201001825B (en) Increasing the in vivo biological activity of biologically active compounds
WO2006127458A3 (en) Novel chemical compounds
DE112006002041A5 (en) Pharmaceutically active composition for the treatment of diabetes

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10755304

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2774494

Country of ref document: CA

Ref document number: 2012529895

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 711/MUMNP/2012

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2010755304

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2010295601

Country of ref document: AU

Ref document number: 2012115097

Country of ref document: RU

ENP Entry into the national phase

Ref document number: 2010295601

Country of ref document: AU

Date of ref document: 20100916

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112012006144

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112012006144

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20120319