WO2010147805A8 - Drug coated balloon catheter and pharmacokinetic profile - Google Patents

Drug coated balloon catheter and pharmacokinetic profile Download PDF

Info

Publication number
WO2010147805A8
WO2010147805A8 PCT/US2010/037799 US2010037799W WO2010147805A8 WO 2010147805 A8 WO2010147805 A8 WO 2010147805A8 US 2010037799 W US2010037799 W US 2010037799W WO 2010147805 A8 WO2010147805 A8 WO 2010147805A8
Authority
WO
WIPO (PCT)
Prior art keywords
balloon
coating
pharmacokinetic profile
balloon catheter
coated balloon
Prior art date
Application number
PCT/US2010/037799
Other languages
French (fr)
Other versions
WO2010147805A3 (en
WO2010147805A2 (en
Inventor
John J. Stankus
Mikael Trollsas
Syed Hossainy
Liangxuan Zhang
Ed Berger
Stephen D. Pacetti
John L. Toner
Original Assignee
Abbott Cardiovascular Systems Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Cardiovascular Systems Inc. filed Critical Abbott Cardiovascular Systems Inc.
Priority to CN201080027624.2A priority Critical patent/CN102481392B/en
Priority to EP10727273.4A priority patent/EP2442840B1/en
Publication of WO2010147805A2 publication Critical patent/WO2010147805A2/en
Publication of WO2010147805A3 publication Critical patent/WO2010147805A3/en
Publication of WO2010147805A8 publication Critical patent/WO2010147805A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/141—Plasticizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Abstract

A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
PCT/US2010/037799 2009-06-17 2010-06-08 Drug coated balloon catheter and pharmacokinetic profile WO2010147805A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201080027624.2A CN102481392B (en) 2009-06-17 2010-06-08 Drug coated balloon catheter and Pharmacokinetic Characteristics
EP10727273.4A EP2442840B1 (en) 2009-06-17 2010-06-08 Drug coated balloon catheter and pharmacokinetic profile

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/486,652 US20100324645A1 (en) 2009-06-17 2009-06-17 Drug coated balloon catheter and pharmacokinetic profile
US12/486,652 2009-06-17

Publications (3)

Publication Number Publication Date
WO2010147805A2 WO2010147805A2 (en) 2010-12-23
WO2010147805A3 WO2010147805A3 (en) 2011-03-10
WO2010147805A8 true WO2010147805A8 (en) 2011-07-14

Family

ID=42709090

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/037799 WO2010147805A2 (en) 2009-06-17 2010-06-08 Drug coated balloon catheter and pharmacokinetic profile

Country Status (4)

Country Link
US (2) US20100324645A1 (en)
EP (1) EP2442840B1 (en)
CN (2) CN102481392B (en)
WO (1) WO2010147805A2 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10076641B2 (en) 2005-05-11 2018-09-18 The Spectranetics Corporation Methods and systems for delivering substances into luminal walls
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
KR101144984B1 (en) 2007-01-21 2012-05-21 헤모텍 아게 Medical product for treating stenosis of body passages and for preventing threatening restenosis
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US20100292641A1 (en) * 2009-05-15 2010-11-18 Bandula Wijay Targeted drug delivery device and method
EP2451496B1 (en) 2009-07-10 2015-07-22 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
WO2011008393A2 (en) 2009-07-17 2011-01-20 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US20110144577A1 (en) * 2009-12-11 2011-06-16 John Stankus Hydrophilic coatings with tunable composition for drug coated balloon
US8480620B2 (en) * 2009-12-11 2013-07-09 Abbott Cardiovascular Systems Inc. Coatings with tunable solubility profile for drug-coated balloon
EP2380604A1 (en) 2010-04-19 2011-10-26 InnoRa Gmbh Improved coating formulations for scoring or cutting balloon catheters
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US20120078227A1 (en) * 2010-09-23 2012-03-29 Boston Scientific Scimed, Inc. Drug Coated Balloon Composition with High Drug Transfer to Vessel
US8961457B2 (en) * 2010-09-30 2015-02-24 Surmodics, Inc. Catheter assembly with guard
WO2013007273A1 (en) * 2011-07-08 2013-01-17 Cardionovum Sp.Z.O.O. Balloon surface coating
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US20140172118A1 (en) * 2012-12-19 2014-06-19 Cook Medical Technologies Llc Bioactive Compositions, Bioactive Eluting Devices and Methods of Use Thereof
US9782516B2 (en) * 2013-03-15 2017-10-10 Abbott Cardiovascular Systems Inc. Tissue adhesive coatings for drug coated balloon
WO2014143043A1 (en) * 2013-03-15 2014-09-18 Abbott Cardiovascular Systems, Inc. Crosslinked coatings delivered via a balloon
WO2014143061A1 (en) * 2013-03-15 2014-09-18 Abbott Cardiovascular Systems, Inc. Electrophoretic balloon and conductive balloon coating
EP2991718B1 (en) * 2013-05-03 2019-11-13 C.R. Bard, Inc. Peelable protective sheath
CN103566414B (en) * 2013-08-13 2016-01-13 重庆大学 A kind of nucleocapsid structure receives particulate coatings intravascular stent and preparation method thereof
US9492594B2 (en) 2014-07-18 2016-11-15 M.A. Med Alliance SA Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs
US11406742B2 (en) 2014-07-18 2022-08-09 M.A. Med Alliance SA Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs
CN104174073B (en) * 2014-08-27 2016-07-06 辽宁生物医学材料研发中心有限公司 A kind of medicine-carrying method of medicine eluting balloon catheter
US20160121027A1 (en) * 2014-10-23 2016-05-05 South Dakota Board Of Regents Formulations for Tailored Drug Release
WO2016141195A1 (en) * 2015-03-04 2016-09-09 Transmed7, Llc Steerable, conformable, drug eluting balloon catheter
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
US20210196932A1 (en) * 2016-02-08 2021-07-01 Orbusneich Medical, Inc. Drug Eluting Balloon
CN106237395B (en) * 2016-09-30 2019-09-20 鼎科医疗技术（苏州）有限公司 A kind of medicine-coated balloon and preparation method thereof
CN106420129B (en) * 2016-11-04 2019-02-01 南京微创医学科技股份有限公司 A kind of drug-carrying self-expansion type non-vascular orifice bracket conveying device
US20190358369A1 (en) 2016-12-22 2019-11-28 Biotronik Ag Drug releasing coatings for medical devices and methods of making same
DE102018100748A1 (en) * 2018-01-15 2019-07-18 Alexander Ruebben Polysaccharidbeschichtung
EP3768338A4 (en) * 2018-03-21 2022-03-23 Meril Life Sciences Pvt Ltd Drug coated balloon
US20220016398A1 (en) * 2018-11-23 2022-01-20 Shanghai Microport Medical (Group) Co., Ltd. Drug eluting balloon and balloon catheter
JP2023535248A (en) 2020-07-29 2023-08-17 バイオトロニック アクチェンゲゼルシャフト Medical devices and methods coated with microsphere drugs
CN115154854B (en) * 2022-04-11 2023-08-15 四川大学华西医院 Double-layer medicine carrying balloon catheter

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5324261A (en) * 1991-01-04 1994-06-28 Medtronic, Inc. Drug delivery balloon catheter with line of weakness
US5545135A (en) * 1994-10-31 1996-08-13 Boston Scientific Corporation Perfusion balloon stent
US20030129215A1 (en) * 1998-09-24 2003-07-10 T-Ram, Inc. Medical devices containing rapamycin analogs
JP3990972B2 (en) * 2001-11-20 2007-10-17 有限会社 キック Vascular restenosis preventing agent and intravascular implant device coated with the preventing agent
EP1569762B1 (en) * 2002-10-22 2007-10-03 Medtronic Vascular, Inc. Stent with intermittent coating
US8088404B2 (en) * 2003-03-20 2012-01-03 Medtronic Vasular, Inc. Biocompatible controlled release coatings for medical devices and related methods
DK1957130T3 (en) * 2005-12-09 2010-11-22 Dsm Ip Assets Bv Hydrophilic coating comprising a polyelectrolyte
US7910152B2 (en) * 2006-02-28 2011-03-22 Advanced Cardiovascular Systems, Inc. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology
US20080057102A1 (en) * 2006-08-21 2008-03-06 Wouter Roorda Methods of manufacturing medical devices for controlled drug release
US20080175887A1 (en) * 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
DE102007036685A1 (en) * 2007-08-03 2009-02-05 Innora Gmbh Improved drug-coated medical devices their manufacture and use
US20090110713A1 (en) * 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
US9198968B2 (en) * 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens

Also Published As

Publication number Publication date
WO2010147805A3 (en) 2011-03-10
CN102481392A (en) 2012-05-30
US20140046254A1 (en) 2014-02-13
EP2442840B1 (en) 2013-10-30
CN104399132A (en) 2015-03-11
EP2442840A2 (en) 2012-04-25
CN104399132B (en) 2017-07-11
US20100324645A1 (en) 2010-12-23
WO2010147805A2 (en) 2010-12-23
CN102481392B (en) 2016-03-30

Similar Documents

Publication Publication Date Title
WO2010147805A3 (en) Drug coated balloon catheter and pharmacokinetic profile
WO2007126768A3 (en) Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
WO2010111232A3 (en) Drug delivery medical device
WO2009014696A3 (en) Medical devices with coatings for delivery of a therapeutic agent
WO2010030995A3 (en) Local delivery of water-soluble or water-insoluble therapeutic agents to the surface body lumens
WO2012009684A3 (en) Drug delivery medical device
WO2008088537A3 (en) Stent with a coating for delivering a therapeutic agent
WO2006020660A3 (en) Coated medical device having an increased coating surface area
WO2008002586A3 (en) Coatings for medical devices comprising a therapeutic agent and a metallic material
WO2010096208A3 (en) Retractable drug delivery system and device
EP4275709A3 (en) Drug-coated balloon catheters for body lumens
EP2500044A3 (en) Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
WO2006014969A3 (en) Medical device having a coating layer with structural elements therein and method of making the same
WO2010129381A3 (en) Balloon coating with drug transfer control via coating thickness
WO2011147407A3 (en) Balloon catheter coated with an anti-restenotic active ingredient and a molecular dispersion agent that promotes transport
AU2014249723B2 (en) Multi-layer biodegradable device having adjustable drug release profile
MX2014007213A (en) Luminal modifications for catheters.
WO2007146426A3 (en) Nanoshells for drug delivery
WO2008144130A3 (en) Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
EP1931281A4 (en) Covered stent with proximal and distal attachment, delivery catheter, and method of making same
WO2010079218A3 (en) Drug-eluting medical device
WO2009099935A3 (en) Drug-coated medical devices for differential drug release
WO2007103296A3 (en) Endoscopic apparatus having an improved catheter
WO2006026187A3 (en) Stents with drug delivery coatings
WO2006124398A3 (en) Methods and systems for delivering substances into luminal walls

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080027624.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10727273

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2010727273

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE