WO2010020021A2 - Laser intradermal therapy procedure - Google Patents

Laser intradermal therapy procedure Download PDF

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Publication number
WO2010020021A2
WO2010020021A2 PCT/BR2008/000250 BR2008000250W WO2010020021A2 WO 2010020021 A2 WO2010020021 A2 WO 2010020021A2 BR 2008000250 W BR2008000250 W BR 2008000250W WO 2010020021 A2 WO2010020021 A2 WO 2010020021A2
Authority
WO
WIPO (PCT)
Prior art keywords
laser
optical fiber
epidermis
procedure
intradermal
Prior art date
Application number
PCT/BR2008/000250
Other languages
French (fr)
Other versions
WO2010020021A3 (en
Inventor
Samir Antonio Elias Arbache
Original Assignee
Samir Antonio Elias Arbache
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samir Antonio Elias Arbache filed Critical Samir Antonio Elias Arbache
Priority to PCT/BR2008/000250 priority Critical patent/WO2010020021A2/en
Publication of WO2010020021A2 publication Critical patent/WO2010020021A2/en
Publication of WO2010020021A3 publication Critical patent/WO2010020021A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00752—Hair removal or transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/00476—Hair follicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2005—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser with beam delivery through an interstitially insertable device, e.g. needle

Definitions

  • the present patent privilege of invention relates to the field of medical procedures and, more particularly, to dermatology procedures with the purpose to define a surgical methodology for wrinkles, hemangiomas, hair follicles and tattoo removal through thermal stimulation or destruction of target-tissues, using an optical fiber with spherical extremity, conventional or directed, which is used to conduct an laser energy to the dermis and subcutaneous tissue through a needle or catheter.
  • the optical fiber goes through the layer of epidermis completely, and is inserted into the lower skin layers, which allows the laser to be applied directly into the target tissue, without hitting the melanin pigment barrier inside the epidermis.
  • the working principle for those external skin laser application treatments is the laser absorption in a specific wave length for a settled chromophore, which was its own absorption spectrum (photoselection) and is located deep into the skin dermis; as each laser emits a specific wave length, it is necessary to choose the specific laser configuration with maximum wave length absorption depending on the target chromophore and also the depth of the desired target tissue, which corresponds to the skin wave length penetration rate.
  • the thermal pulse generated by the laser equipment on the target-tissue causes an inflammatory response in the walls of micro-vessels releasing chemical triggers, which stimulates the fibroblasts cells to replace the damaged collagen with new one.
  • the treatment can ' t be applied on dark skin or tanned people due to the large amount of melanin pigments inside their epidermis; 4- Its necessary the use of several lasers types in order to change the wave length applied to the skin according to the target tissue depth and / or the photoselection of the target-tissue;
  • the therapy can ' t be applied on small targets, due to the size of regular market laser emission devices, and is not effective on wrinkles removal on delicate human body regions such as around the eyes and around the lips;
  • the proposed surgical therapy establishes that the optical fiber goes through the layer of epidermis completely, and it can be inserted deeply into any desired skin lower layers, which allows the laser to be applied directly into the target tissue, without hitting the melanin pigment barrier inside the epidermis; as a result, it is possible to use lower laser energies (fluences) on the epidermis layer, in comparison with the prior art techniques, and the epidermis layer is not heated or damaged, which allows the use of the therapy on dark skin or tanned people; the therapy also allows the use of just one kind of laser equipment, because there is no need for several wave length; it also allows the use on small targets, due to the small size of the optical fiber and allows the doctor to control how deep to insert and the exact location of the optical fiber as it moves along the target-tissues, using the guide laser light.
  • FIG. 1 - Shows a side section view of a laser application process outside the epidermis, where can be seen the melanin pigment inside the epidermis layer absorbing most of the laser energy and only a small part of this energy reaching the target- tissue.
  • FIG. 2 - Shows a side section view of a laser intradermal therapy procedure, where can be seen the optical fiber going through the layer of epidermis completely, and the laser is applied directly on the target tissue, allowing the use of just the necessary energy recommended for each treatment.
  • FIG. 3 - Shows a side section view of a laser intradermal therapy procedure, where the laser is applied beneath the epidermis and there are two enlarged details showing the optical fiber spherical extremity, in order to gain better laser radial dispersion or focus on aimed tissue regions, positioned in front of the needle or inside a catheter, for laser side dispersion.
  • FIG. 4 - Shows the optical fiber being directed towards the lower eyelid wrinkles, which are not accessible using other wrinkles removal techniques; the line shows the optical fiber location and the circle the therapeutic laser beam.
  • FIG. 5 - Shows the wrinkles marked with special pen marking the regions where the optical fiber will move along the target-tissues.
  • FIG. 6 - Shows the laser intradermal therapy procedure around the eyes of a hypothetical patient.
  • FIG. 7 - Shows the laser intradermal therapy procedure around the lips of a hypothetical patient.
  • the laser intradermal therapy procedure, the optical fiber (9), goes completely through the layer of epidermis (6), using of a needle (10), or catheter (11), for skin punching and allowing the laser (1), to be applied directly on the target tissue (5), inside the dermis and subcutaneous tissue (7), without being absorbed by the melanin pigments (2); as a result, it is possible to use lower laser energies (1), in comparison with conventional techniques, and allowing the use of just one kind of laser emission equipment.
  • the optical fiber (9), in the laser intradermal therapy procedure, can be used with a needle (10), or catheter (11), which can be connected to a common market hand-piece device (12); when used with the needle (10), the optical fiber spherical extremity (9), is located in front of the needle's tip, allowing laser (1), radial dispersion or focus; when used with the catheter (11 ), generates laser side dispersion.
  • the laser intradermal therapy procedure allows to treat body regions which are not accessible using other wrinkles removal techniques, such as the lower eyelid wrinkles.
  • the procedure can be made by marking the wrinkles with specific pen, allowing the doctor, through the laser beam guide light, the exact knowledge of the optical fiber (9), position beneath the skin, increasing the treatment precision and allowing the use on delicate and difficult to reach parts of human body such as around the eyes and around the lips.

Abstract

Laser intradermal therapy procedure, is a surgical procedure for wrinkles, hemangiomas, hair follicles and tattoo removal through thermal stimulation or destruction of target-tissues, using an optical fiber with spherical extremity (9), which is used to conduct a laser energy (1), to the dermis and subcutaneous tissue (7), through a needle (10), or catheter (11), which can be connected to a hand-piece device (12); the optical fiber (9), goes completely through the layer of epidermis (6), and is introduced into any desired skin depth (7), allowing the laser (1), to be applied directly on the target tissue (5), without being absorbed by the melanin pigments (2), inside the epidermis; as a result, it allows the treatment of dark skin or tanned patients and allows the doctor to control exactly the area and the depth were the laser (1), will act with best therapeutic results with no energy lost or excessive patient exposure; as a consequence, the procedure allows the use of lower laser energies compared to conventional laser application outside the skin (3); the procedure is also very precise, safe and specific, allowing the doctor to know, through the laser beam guide light, the exact location of the optical fiber (9), position beneath the skin, increasing the treatment precision and positive results.

Description

"LASER INTRADERMAL THERAPY PROCEDURE"
Field of the invention
The present patent privilege of invention relates to the field of medical procedures and, more particularly, to dermatology procedures with the purpose to define a surgical methodology for wrinkles, hemangiomas, hair follicles and tattoo removal through thermal stimulation or destruction of target-tissues, using an optical fiber with spherical extremity, conventional or directed, which is used to conduct an laser energy to the dermis and subcutaneous tissue through a needle or catheter.
The optical fiber goes through the layer of epidermis completely, and is inserted into the lower skin layers, which allows the laser to be applied directly into the target tissue, without hitting the melanin pigment barrier inside the epidermis.
Background of the invention
Currently, there are several laser treatments available for wrinkles removal, increasing collagen production, and also for destruction of hemangiomas, hair follicles and tattoos through laser application on regions outside the epidermis as, for example, "The TernaScan process" (www.sciton.com), the "Fraxel™ SR Laser" (fractional photothermolysis method) and the "Versa Pulse" (www.surgical.lumenis.com/wt/page/versapulse).
The working principle for those external skin laser application treatments is the laser absorption in a specific wave length for a settled chromophore, which was its own absorption spectrum (photoselection) and is located deep into the skin dermis; as each laser emits a specific wave length, it is necessary to choose the specific laser configuration with maximum wave length absorption depending on the target chromophore and also the depth of the desired target tissue, which corresponds to the skin wave length penetration rate.
Regarding the wrinkles removal, the thermal pulse generated by the laser equipment on the target-tissue, causes an inflammatory response in the walls of micro-vessels releasing chemical triggers, which stimulates the fibroblasts cells to replace the damaged collagen with new one.
As academic references for medical laser intradermal procedures using optical fibers, can be quoted the procedure for subcutaneous tissue liposuction using optical fibers (Submental Nd:YAG Laser-Assisted Liposuction) according to article from Dr Alberto Goldman and the procedure to heat skin sweat glands (Subdermal Nd-YAG Laser for Axillary Hyperhidrosis) according to article from Dr Alberto Goldman and Dr Uwe Wollina.
Prior art disadvantages
On the reported prior art techniques for laser application outside the epidermis, a large amount of the therapeutic laser light is absorbed by the melanin pigments, with is responsible for the skin color and is located inside the epidermis layer; as a result, there is a number of technical limitations and problems, which includes the following:
1 - It is necessary to use high laser energies (fluences) on the epidermis layer in order to guarantee that small percentages of the initial energy reaches the target dermis or subcutaneous tissues and creates the expected thermal effects;
2 - Generates high temperatures on epidermis surface, which causes patient's discomfort and the need for the use of cooling devices or a couplant gel, and, in some cases, the use of anaesthetic;
3 - The treatment can't be applied on dark skin or tanned people due to the large amount of melanin pigments inside their epidermis; 4- Its necessary the use of several lasers types in order to change the wave length applied to the skin according to the target tissue depth and / or the photoselection of the target-tissue;
5- The therapy can't be applied on small targets, due to the size of regular market laser emission devices, and is not effective on wrinkles removal on delicate human body regions such as around the eyes and around the lips;
6 - Causes epidermis damage and, in many cases, skin spots and scars; 7 - Allows limited control of the procedure by the doctor;
The limitations and disadvantages on the above quoted academic medical laser intradermal treatments using optical fibers, resides in the fact that they have a very specific application, respectively, for subcutaneous tissue liposuction and for heating skin sweat glands; as a result, they can't be used for other applications and demands large doctor skills for its effective use.
Summary of the invention Due the problems quoted above, and after large research and studies, the inventor, dermatologist who has experience in the field of medical laser equipments, invented and developed an innovative intradermal surgery therapy for wrinkles, hemangiomas, hair follicles and tattoo removal through thermal stimulation or destruction of dermis and subcutaneous target- tissues, using an optical fiber with spherical extremity, which is used to conduct an laser energy and is inserted into dermis and subcutaneous tissues using a needle or catheter.
The proposed surgical therapy establishes that the optical fiber goes through the layer of epidermis completely, and it can be inserted deeply into any desired skin lower layers, which allows the laser to be applied directly into the target tissue, without hitting the melanin pigment barrier inside the epidermis; as a result, it is possible to use lower laser energies (fluences) on the epidermis layer, in comparison with the prior art techniques, and the epidermis layer is not heated or damaged, which allows the use of the therapy on dark skin or tanned people; the therapy also allows the use of just one kind of laser equipment, because there is no need for several wave length; it also allows the use on small targets, due to the small size of the optical fiber and allows the doctor to control how deep to insert and the exact location of the optical fiber as it moves along the target-tissues, using the guide laser light.
The characterization of the present patent privilege of invention request is made using drawings to illustrate the "LASER INTRADERMAL THERAPY PROCEDURE", in a way that the methodology can be fully reproduced using a suitable technique.
From the elaborate figures, the descriptive part of this report is substantiate and, through detailed and consecutive numbered figures, it clarifies aspects which may be not fully understood.
Those figures are illustrative only, and may present variations.
Brief description of drawings
For better understanding of the claimed object "LASER INTRADERMAL THERAPY PROCEDURE", follows a description of the illustrative drawings attached, where can be seen:
FIG. 1 - Shows a side section view of a laser application process outside the epidermis, where can be seen the melanin pigment inside the epidermis layer absorbing most of the laser energy and only a small part of this energy reaching the target- tissue.
FIG. 2 - Shows a side section view of a laser intradermal therapy procedure, where can be seen the optical fiber going through the layer of epidermis completely, and the laser is applied directly on the target tissue, allowing the use of just the necessary energy recommended for each treatment.
FIG. 3 - Shows a side section view of a laser intradermal therapy procedure, where the laser is applied beneath the epidermis and there are two enlarged details showing the optical fiber spherical extremity, in order to gain better laser radial dispersion or focus on aimed tissue regions, positioned in front of the needle or inside a catheter, for laser side dispersion. FIG. 4 - Shows the optical fiber being directed towards the lower eyelid wrinkles, which are not accessible using other wrinkles removal techniques; the line shows the optical fiber location and the circle the therapeutic laser beam.
FIG. 5 - Shows the wrinkles marked with special pen marking the regions where the optical fiber will move along the target-tissues.
FIG. 6 - Shows the laser intradermal therapy procedure around the eyes of a hypothetical patient.
FIG. 7 - Shows the laser intradermal therapy procedure around the lips of a hypothetical patient.
Detailed description of invention
In accordance with figure 1 , during the laser application outside the epidermis (6), which is generated in a conventional laser equipment (3), a significant part of the laser light energy (1), is absorbed by the melanin pigments (2), which is located inside e epidermis (6); this process generates a region with high temperatures (4), and, as a result, the need to use cooling devices or a couplant gel (8); as result, it is necessary to use high laser energies (fluence) in order to guarantee that small percentages of the initial energy reaches the target-tissues (5), inside the layers of dermis or subcutaneous tissues (7), and creates the expected thermal effects.
In accordance with figure 2, the laser intradermal therapy procedure, the optical fiber (9), goes completely through the layer of epidermis (6), using of a needle (10), or catheter (11), for skin punching and allowing the laser (1), to be applied directly on the target tissue (5), inside the dermis and subcutaneous tissue (7), without being absorbed by the melanin pigments (2); as a result, it is possible to use lower laser energies (1), in comparison with conventional techniques, and allowing the use of just one kind of laser emission equipment.
In accordance with figure 3, in the laser intradermal therapy procedure, the optical fiber (9), can be used with a needle (10), or catheter (11), which can be connected to a common market hand-piece device (12); when used with the needle (10), the optical fiber spherical extremity (9), is located in front of the needle's tip, allowing laser (1), radial dispersion or focus; when used with the catheter (11 ), generates laser side dispersion. In accordance with figure 4, the laser intradermal therapy procedure allows to treat body regions which are not accessible using other wrinkles removal techniques, such as the lower eyelid wrinkles. In accordance with figures 5, 6 and 7, the procedure can be made by marking the wrinkles with specific pen, allowing the doctor, through the laser beam guide light, the exact knowledge of the optical fiber (9), position beneath the skin, increasing the treatment precision and allowing the use on delicate and difficult to reach parts of human body such as around the eyes and around the lips.
For the offered advantages and for it's truly innovative characteristics, which fulfill the originality requisitions, the presented "LASER INTRADERMAL THERAPY PROCEDURE" has all the necessary and sufficient conditions to deserve the patent privilege of invention.

Claims

CLAIMS:
1. "LASER INTRADERMAL THERAPY PROCEDURE", has the purpose to define a surgery procedure for wrinkles, hemangiomas, hair follicles and tattoo removal through thermal stimulation or destruction of target-tissues, avoiding the epidermis (6), to be damaged, and is defined for using an optical fiber (9), conventional or directed, which is used to conduct an laser energy (1 ), into the dermis and subcutaneous tissue (7), through a needle (10), or catheter (11), which can be connected to a hand- piece device (12).
2. "LASER INTRADERMAL THERAPY PROCEDURE", in accordance with claim 1 , wherein uses an optical fiber (9), which goes completely through the layer of epidermis (6), and introduced into any desired skin depth (7), allowing the laser (1 ), to be applied directly into the target tissue (5), without hitting the melanin pigment barrier (2), inside the epidermis.
3. "LASER INTRADERMAL THERAPY PROCEDURE", in accordance with claim 1 , wherein allows the use of the therapy on dark skin or tanned people.
4. "LASER INTRADERMAL THERAPY
PROCEDURE", in accordance with claim 1 , wherein uses lower laser energies (fluences), in comparison with conventional laser outside the epidermis techniques, with the same final results.
5. "LASER INTRADERMAL THERAPY PROCEDURE", in accordance with claim 1 , wherein uses an optical fiber with spherical extremity (9), allowing the laser radial dispersion or focus on target tissue regions.
6. "LASER INTRADERMAL THERAPY PROCEDURE", in accordance with claim 1 , wherein uses optical fiber protocols with preference for 200 to 1000 micra.
PCT/BR2008/000250 2008-08-21 2008-08-21 Laser intradermal therapy procedure WO2010020021A2 (en)

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US8894678B2 (en) 2009-08-07 2014-11-25 Ulthera, Inc. Cellulite treatment methods
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9039722B2 (en) 2007-10-09 2015-05-26 Ulthera, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
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US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US10238674B2 (en) 2010-07-12 2019-03-26 The Regents Of The University Of California Bovine milk oligosaccharides
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FR2875122A1 (en) * 2004-09-14 2006-03-17 Anastasie Bruno Medical endo-vascular instrument for laser treatment of varicose veins, comprises optical fiber with rigid support

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US9364246B2 (en) 2005-09-07 2016-06-14 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9005229B2 (en) 2005-09-07 2015-04-14 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US9272124B2 (en) 2005-12-02 2016-03-01 Ulthera, Inc. Systems and devices for selective cell lysis and methods of using same
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US10220122B2 (en) 2007-10-09 2019-03-05 Ulthera, Inc. System for tissue dissection and aspiration
US9039722B2 (en) 2007-10-09 2015-05-26 Ulthera, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8900262B2 (en) 2009-08-07 2014-12-02 Ulthera, Inc. Device for dissection of subcutaneous tissue
US9044259B2 (en) 2009-08-07 2015-06-02 Ulthera, Inc. Methods for dissection of subcutaneous tissue
US8979881B2 (en) 2009-08-07 2015-03-17 Ulthera, Inc. Methods and handpiece for use in tissue dissection
US8920452B2 (en) 2009-08-07 2014-12-30 Ulthera, Inc. Methods of tissue release to reduce the appearance of cellulite
US8894678B2 (en) 2009-08-07 2014-11-25 Ulthera, Inc. Cellulite treatment methods
US8906054B2 (en) 2009-08-07 2014-12-09 Ulthera, Inc. Apparatus for reducing the appearance of cellulite
US9510849B2 (en) 2009-08-07 2016-12-06 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9757145B2 (en) 2009-08-07 2017-09-12 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9078688B2 (en) 2009-08-07 2015-07-14 Ulthera, Inc. Handpiece for use in tissue dissection
US11337725B2 (en) 2009-08-07 2022-05-24 Ulthera, Inc. Handpieces for tissue treatment
US10271866B2 (en) 2009-08-07 2019-04-30 Ulthera, Inc. Modular systems for treating tissue
US10485573B2 (en) 2009-08-07 2019-11-26 Ulthera, Inc. Handpieces for tissue treatment
US10531888B2 (en) 2009-08-07 2020-01-14 Ulthera, Inc. Methods for efficiently reducing the appearance of cellulite
US8900261B2 (en) 2009-08-07 2014-12-02 Ulthera, Inc. Tissue treatment system for reducing the appearance of cellulite
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US10603066B2 (en) 2010-05-25 2020-03-31 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10918653B2 (en) 2010-07-12 2021-02-16 The Regents Of The University Of California Bovine milk oligosaccharides
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