WO2009006075A3 - Functionalized expanded porphyrins - Google Patents

Functionalized expanded porphyrins Download PDF

Info

Publication number
WO2009006075A3
WO2009006075A3 PCT/US2008/067904 US2008067904W WO2009006075A3 WO 2009006075 A3 WO2009006075 A3 WO 2009006075A3 US 2008067904 W US2008067904 W US 2008067904W WO 2009006075 A3 WO2009006075 A3 WO 2009006075A3
Authority
WO
WIPO (PCT)
Prior art keywords
disclosed
expanded porphyrins
functionalized expanded
functionalized
methods
Prior art date
Application number
PCT/US2008/067904
Other languages
French (fr)
Other versions
WO2009006075A2 (en
Inventor
Jonathan L Sessler
Patricia J Melfi
Original Assignee
Univ Texas
Jonathan L Sessler
Patricia J Melfi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Jonathan L Sessler, Patricia J Melfi filed Critical Univ Texas
Priority to US12/664,524 priority Critical patent/US8580845B2/en
Publication of WO2009006075A2 publication Critical patent/WO2009006075A2/en
Publication of WO2009006075A3 publication Critical patent/WO2009006075A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine

Abstract

Disclosed are functionalized expanded porphyrins that can be used as spectrometric sensors for high-valent actinide cations. The disclosed functionalized expanded porphyrins have the advantage over unfunctionalized systems in that they can be immobilized via covalent attachment to a solid support comprising an inorganic or organic polymer or other common substrates. Substrates comprising the disclosed functionalized expanded porphyrins are also disclosed. Further, disclosed are methods of making the disclosed compounds (immobilized and free), methods of using them as sensors to detect high valent actinides, devices that comprise the disclosed compounds, and kits.
PCT/US2008/067904 2007-06-29 2008-06-23 Functionalized expanded porphyrins WO2009006075A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/664,524 US8580845B2 (en) 2007-06-29 2008-06-23 Functionalized expanded porphyrins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93767607P 2007-06-29 2007-06-29
US60/937,676 2007-06-29

Publications (2)

Publication Number Publication Date
WO2009006075A2 WO2009006075A2 (en) 2009-01-08
WO2009006075A3 true WO2009006075A3 (en) 2009-08-20

Family

ID=40226758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/067904 WO2009006075A2 (en) 2007-06-29 2008-06-23 Functionalized expanded porphyrins

Country Status (2)

Country Link
US (1) US8580845B2 (en)
WO (1) WO2009006075A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8802074B2 (en) 2008-11-26 2014-08-12 Board Of Regents, The University Of Texas System Polymers functionalized with ion-specific recognition elements
EP2835054A1 (en) 2013-08-05 2015-02-11 Nimartech Limited Porphyrinoid compounds, method and apparatus for water photodisinfection.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410045A (en) * 1992-08-04 1995-04-25 Board Of Regents, The University Of Texas System Rubyrin and related expanded porphyrins
US20040152826A1 (en) * 2002-03-28 2004-08-05 The Trustees Of The University Of Pennsylvania Synthesis, spectroscopy, photophysics of multi-chromophoric Zn(II) group 8 metal complexes
US20050137180A1 (en) * 2001-05-31 2005-06-23 Miravant Pharmaceuticals, Inc. Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
US6984734B2 (en) * 2002-02-26 2006-01-10 Board Of Regents, The University Of Texas System Cyclo[n]pyrroles and methods thereto

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US556552A (en) * 1896-03-17 Walter a
US5559207A (en) 1989-03-06 1996-09-24 Board Of Regents, University Of Texas Texaphyrin metal complex mediated ester hydrolysis
US5162509A (en) 1989-03-06 1992-11-10 Board Of Regents, The University Of Texas System Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US4935498A (en) 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5252720A (en) 1989-03-06 1993-10-12 Board Of Regents, The University Of Texas System Metal complexes of water soluble texaphyrins
US5599923A (en) 1989-03-06 1997-02-04 Board Of Regents, University Of Tx Texaphyrin metal complexes having improved functionalization
US5457183A (en) 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5543514A (en) 1989-12-21 1996-08-06 Board Of Regents, The University Of Texas System Water-soluble sapphyrins
US5159065A (en) 1989-12-21 1992-10-27 Board Of Regents, The University Of Texas System Sapphyrins, derivatives and syntheses
US5457195A (en) 1989-12-21 1995-10-10 Board Of Regents, The University Of Texas System Sapphyrin derivatives and conjugates
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US7041819B2 (en) 1996-04-05 2006-05-09 Board Of Regents, The University Of Texas System Halogenated calixpyrroles and uses thereof
US6262257B1 (en) 1996-04-05 2001-07-17 Board Of Regents, University Of Texas System Calixpyrroles, calixpyridinopyrroles and calixpyridines
US5756724A (en) 1997-04-22 1998-05-26 Cytopharm, Inc. High-yielding ullmann reaction for the preparation of bipyrroles
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6602702B1 (en) 1999-07-16 2003-08-05 The University Of Texas System Detection system based on an analyte reactive particle
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410045A (en) * 1992-08-04 1995-04-25 Board Of Regents, The University Of Texas System Rubyrin and related expanded porphyrins
US20050137180A1 (en) * 2001-05-31 2005-06-23 Miravant Pharmaceuticals, Inc. Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
US6984734B2 (en) * 2002-02-26 2006-01-10 Board Of Regents, The University Of Texas System Cyclo[n]pyrroles and methods thereto
US20040152826A1 (en) * 2002-03-28 2004-08-05 The Trustees Of The University Of Pennsylvania Synthesis, spectroscopy, photophysics of multi-chromophoric Zn(II) group 8 metal complexes

Also Published As

Publication number Publication date
US20100197031A1 (en) 2010-08-05
US8580845B2 (en) 2013-11-12
WO2009006075A2 (en) 2009-01-08

Similar Documents

Publication Publication Date Title
WO2009035528A3 (en) Synthetic lipid a derivative
WO2012082213A3 (en) Conductive open frameworks
WO2008022332A3 (en) System, method and kit for replicating a dna array
WO2010124184A3 (en) Occasional access to a wireless network
WO2005041902A3 (en) Anion-binding polymers and uses thereof
WO2008057502A3 (en) Content borrowing system and method
WO2012027538A3 (en) Metal organic framework modified materials, methods of making and methods of using same
WO2009009188A3 (en) Uses of water-dispersible silica nanoparticles for attaching biomolecules
WO2008114139A3 (en) System and methods for biomass processing
WO2010088517A8 (en) Methods and systems for purifying transferring and/or manipulating nucleic acids
WO2010088633A3 (en) Novel cell lines and methods
EP2288724B8 (en) Methods and systems for universal carrier screening
WO2007039907A3 (en) Methods and systems for updating content including a compressed version
WO2009085573A3 (en) Quality control cell device for immunohistochemistry assay and methods of use thereof
EP2198398A4 (en) Crm system and method having drilldowns, acls, shared folders, a tracker and a module builder
EP2120842A4 (en) Hybrid organic/inorganic chemical hybrid systems, including functionalized calcium phosphate hybrid systems, and a solid-state method of producing the same
WO2010135356A8 (en) Bioprocessing
EP1824907A4 (en) Functional organic particle, and method for preparing the same
WO2009102569A3 (en) Cell lines and methods for making and using them
WO2009006075A3 (en) Functionalized expanded porphyrins
FR2930558B1 (en) SILICA PARTICLE COMPRISING AN ORGANOLANTHANIDE COMPOUND, PROCESS FOR PREPARATION AND USES
WO2008119002A3 (en) Methods and systems for providing direct manufactured interconnecting assemblies
WO2008064222A3 (en) Shade tolerance in plants
WO2014008167A3 (en) Cell-based assays for post-translational enzyme activity
WO2011092504A3 (en) Biomarkers for schizophrenia

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12664524

Country of ref document: US

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08826057

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 08826057

Country of ref document: EP

Kind code of ref document: A2