WO2008151049A3 - Nucleic acid functionalized nanoparticles for therapeutic applications - Google Patents
Nucleic acid functionalized nanoparticles for therapeutic applications Download PDFInfo
- Publication number
- WO2008151049A3 WO2008151049A3 PCT/US2008/065366 US2008065366W WO2008151049A3 WO 2008151049 A3 WO2008151049 A3 WO 2008151049A3 US 2008065366 W US2008065366 W US 2008065366W WO 2008151049 A3 WO2008151049 A3 WO 2008151049A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- therapeutic applications
- functionalized nanoparticles
- acid functionalized
- materials
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008259907A AU2008259907B2 (en) | 2007-05-30 | 2008-05-30 | Nucleic acid functionalized nanoparticles for therapeutic applications |
MX2009013046A MX2009013046A (en) | 2007-05-30 | 2008-05-30 | Nucleic acid functionalized nanoparticles for therapeutic applications. |
DK08756546.1T DK2160464T3 (en) | 2007-05-30 | 2008-05-30 | NUCLEIC ACID FUNCTIONALIZED NANOPARTICLES FOR THERAPEUTIC APPLICATIONS |
CA2689923A CA2689923A1 (en) | 2007-05-30 | 2008-05-30 | Nucleic acid functionalized nanoparticles for therapeutic applications |
EP08756546.1A EP2160464B1 (en) | 2007-05-30 | 2008-05-30 | Nucleic acid functionalized nanoparticles for therapeutic applications |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94088607P | 2007-05-30 | 2007-05-30 | |
US60/940,886 | 2007-05-30 | ||
US98546207P | 2007-11-05 | 2007-11-05 | |
US60/985,462 | 2007-11-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008151049A2 WO2008151049A2 (en) | 2008-12-11 |
WO2008151049A3 true WO2008151049A3 (en) | 2009-02-05 |
Family
ID=39708942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/065366 WO2008151049A2 (en) | 2007-05-30 | 2008-05-30 | Nucleic acid functionalized nanoparticles for therapeutic applications |
Country Status (7)
Country | Link |
---|---|
US (2) | US9506056B2 (en) |
EP (2) | EP2160464B1 (en) |
AU (1) | AU2008259907B2 (en) |
CA (2) | CA3055145A1 (en) |
DK (2) | DK2160464T3 (en) |
MX (1) | MX2009013046A (en) |
WO (1) | WO2008151049A2 (en) |
Cited By (1)
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US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
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AU2008259907B2 (en) | 2007-05-30 | 2014-12-04 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
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AU2009316286B2 (en) * | 2008-11-24 | 2016-05-26 | Northwestern University | Polyvalent RNA-nanoparticle compositions |
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- 2008-05-30 CA CA3055145A patent/CA3055145A1/en not_active Abandoned
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- 2008-05-30 EP EP08756546.1A patent/EP2160464B1/en not_active Not-in-force
- 2008-05-30 MX MX2009013046A patent/MX2009013046A/en active IP Right Grant
- 2008-05-30 WO PCT/US2008/065366 patent/WO2008151049A2/en active Application Filing
- 2008-05-30 US US12/130,643 patent/US9506056B2/en not_active Expired - Fee Related
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2016
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Patent Citations (1)
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WO2006012695A1 (en) * | 2004-08-04 | 2006-02-09 | Panvax Limited | An immunogenic composition |
Non-Patent Citations (4)
Title |
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CHITHRANI B DEVIKA ET AL: "Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.", NANO LETTERS APR 2006, vol. 6, no. 4, April 2006 (2006-04-01), pages 662 - 668, XP002493714, ISSN: 1530-6984 * |
GILJOHANN DAVID A ET AL: "Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles.", NANO LETTERS DEC 2007, vol. 7, no. 12, December 2007 (2007-12-01), pages 3818 - 3821, XP002493715, ISSN: 1530-6984 * |
ROSI NATHANIEL L ET AL: "Oligonucleotide-modified gold nanoparticles for intracellular gene regulation", SCIENCE (NEW YORK, N.Y.) 19 MAY 2006,, vol. 312, no. 5776, 19 May 2006 (2006-05-19), pages 1027 - 1030, XP002489177 * |
YIN WIN K ET AL: "Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 15, 1 May 2005 (2005-05-01), pages 2713 - 2722, XP004673437, ISSN: 0142-9612 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
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US9506056B2 (en) | 2016-11-29 |
AU2008259907B2 (en) | 2014-12-04 |
US20080306016A1 (en) | 2008-12-11 |
EP2826863A1 (en) | 2015-01-21 |
US20170137809A1 (en) | 2017-05-18 |
MX2009013046A (en) | 2010-02-17 |
US10370656B2 (en) | 2019-08-06 |
EP2160464A2 (en) | 2010-03-10 |
WO2008151049A2 (en) | 2008-12-11 |
DK2826863T3 (en) | 2017-12-04 |
AU2008259907A1 (en) | 2008-12-11 |
CA3055145A1 (en) | 2008-12-11 |
CA2689923A1 (en) | 2008-12-11 |
EP2160464B1 (en) | 2014-05-21 |
DK2160464T3 (en) | 2014-08-04 |
EP2826863B1 (en) | 2017-08-23 |
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