WO2008140484A3 - Methods for diagnosing and monitoring the status of systemic lupus erythematosus - Google Patents

Methods for diagnosing and monitoring the status of systemic lupus erythematosus Download PDF

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Publication number
WO2008140484A3
WO2008140484A3 PCT/US2007/023675 US2007023675W WO2008140484A3 WO 2008140484 A3 WO2008140484 A3 WO 2008140484A3 US 2007023675 W US2007023675 W US 2007023675W WO 2008140484 A3 WO2008140484 A3 WO 2008140484A3
Authority
WO
WIPO (PCT)
Prior art keywords
status
diagnosing
monitoring
lupus erythematosus
systemic lupus
Prior art date
Application number
PCT/US2007/023675
Other languages
French (fr)
Other versions
WO2008140484A2 (en
Inventor
Preeti G. Lal
Gavin E. Williams
Kirk E. Fry
Jingtao Sun
Russell L. Dedrick
Original Assignee
Xdx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xdx, Inc. filed Critical Xdx, Inc.
Priority to EP20070874123 priority Critical patent/EP2102367A2/en
Publication of WO2008140484A2 publication Critical patent/WO2008140484A2/en
Publication of WO2008140484A3 publication Critical patent/WO2008140484A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Abstract

The invention presents a method of diagnosing or monitoring the status of systemic lupus erythematosus (SLE) in a subject or patient comprising detecting the expression of all genes of a diagnostic set in the subject or patient wherein the diagnostic set comprises two or more genes having expression correlated with the classification or status of SLE; and diagnosing or monitoring the status of SLE in the subject or patient by applying at least one statistical method to the expression of the genes of the diagnostic set.
PCT/US2007/023675 2006-11-09 2007-11-09 Methods for diagnosing and monitoring the status of systemic lupus erythematosus WO2008140484A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20070874123 EP2102367A2 (en) 2006-11-09 2007-11-09 Methods for diagnosing and monitoring the status of systemic lupus erythematosus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85814706P 2006-11-09 2006-11-09
US60/858,147 2006-11-09

Publications (2)

Publication Number Publication Date
WO2008140484A2 WO2008140484A2 (en) 2008-11-20
WO2008140484A3 true WO2008140484A3 (en) 2009-10-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023675 WO2008140484A2 (en) 2006-11-09 2007-11-09 Methods for diagnosing and monitoring the status of systemic lupus erythematosus

Country Status (3)

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US (1) US8148067B2 (en)
EP (1) EP2102367A2 (en)
WO (1) WO2008140484A2 (en)

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